Results 101 to 110 of about 9,275 (242)

Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel NaV1.7

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Gain-of-function mutations in voltage-gated sodium channel NaV1.7 cause the severe inherited pain syndrome inherited erythromelalgia (IEM).
G. Wisedchaisri, Tamer M. Gamal El-Din, Ning Zheng, W. Catterall   +3 more
semanticscholar   +1 more source

Distribution of Voltage‐Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
Various sodium channel isoforms and their scaffolding proteins are found in four different microdomains in vestibular calyx‐bearing afferents. These microdomains serve different purposes, analogous to the heminode, axon initial segment, and synaptic domains of other types of sensory afferents.
Anna Lysakowski, Aravind Chenrayan Govindaraju, Steven D. Price, Sophie Gaboyard‐Niay, Irina Calin‐Jageman, Robstein L. Chidavaenzi, Ruth Anne Eatock, Robert M. Raphael, Jay M. Goldberg   +8 more
wiley   +1 more source

Basic aspects of the pharmacodynamics of tolperisone, a widely applicable centrally acting muscle relaxant [PDF]

, 2014
Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated skeletal muscle tone
Bajaj P, Dulin J, Farkas S, Fels G, Fujioka M, Funakoshi M, Funakoshi M, Gold R, Goldin A L, Hinck D, Hinck D, Hofer D, Kocsis P, Kocsis P, Kornelia Tekes, Lipták J, Luo Z, Melka A, Novales-Li P, Novales-Li P, Nádor K, Okada H, Ono H, Patel KS, Prabhoo R, Pratzel HG, Pórszász J, Quasthoff S, Quasthoff S, Rao R, Sakaue A, Sakitama K, Sakitama K, Stamenova P, Svensson P, Vora A, Zhao F   +36 more
core   +1 more source

Optimizing Nav1.7‐Targeted Analgesics: Revealing Off‐Target Effects of Spider Venom‐Derived Peptide Toxins and Engineering Strategies for Improvement

Advancement of science
The inhibition of Nav1.7 is a promising strategy for the development of analgesic treatments. Spider venom‐derived peptide toxins are recognized as significant sources of Nav1.7 inhibitors.
Sen Luo, Xi Zhou, Meijing Wu, Gongxin Wang, Li Wang, Xujun Feng, Hang Wu, Ren Luo, Minjuan Lu, Junxian Ju, Wenxing Wang, Lei Yuan, Xiaoqing Luo, Dezheng Peng, Li Yang, Qingfeng Zhang, Minzhi Chen, Songping Liang, Xiuming Dong, Guoliang Hao, Yunxiao Zhang, Zhonghua Liu   +21 more
semanticscholar   +1 more source

Sodium channels Nav1.7, Nav1.8 and pain; two distinct mechanisms for Nav1.7 null analgesia

Neurobiology of Pain
Genetic deletion and pharmacological inhibition are distinct approaches to unravelling pain mechanisms, identifying targets and developing new analgesics. Both approaches have been applied to the voltage-gated sodium channels Nav1.7 and Nav1.8. Genetic deletion of Nav1.8 in mice leads to a loss of pain and antagonists are effective analgesics.
Federico Iseppon, Alexandros H. Kanellopoulos, Naxi Tian, Gozde Caan, R. Chiozzi, Konstantinos Thalassinos, C. Çubuk, Myles J. Lewis, James J. Cox, Jing Zhao, C. G. Woods, John N. Wood   +11 more
semanticscholar   +3 more sources

The C-Terminal of NaV1.7 Is Ubiquitinated by NEDD4L

ACS Bio & Med Chem Au, 2023
NaV1.7, the neuronal voltage-gated sodium channel isoform, plays an important role in the human body’s ability to feel pain. Mutations within NaV1.7 have been linked to pain-related syndromes, such as insensitivity to pain.
Katharine M. Wright, Hanjie Jiang, Wendy Xia, Michael B. Murphy, T. Boronina, Justin N. Nwafor, Hyojeon Kim, A. Iheanacho, P. Azurmendi, Robert N Cole, Philip A. Cole, S. Gabelli   +11 more
semanticscholar   +1 more source

Parallel Evolution of Tetrodotoxin Resistance in Three Voltage-Gated Sodium Channel Genes in the Garter Snake Thamnophis sirtalis [PDF]

, 2014
Members of a gene family expressed in a single species often experience common selection pressures. Consequently, the molecular basis of complex adaptations may be expected to involve parallel evolutionary changes in multiple paralogs.
Brodie, Edmund D., Chuckalovcak, John P., Edwards, Scott V., Feldman, Chris R., Janes, Daniel E., McGlothlin, Joel W., Pfrender, Michael E.   +6 more
core   +1 more source

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1 [PDF]

, 2017
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the ...
Brierley, Stuart M, Caldwell, Ashlee, Castro, Joel, Deuis, Jennifer R, Erickson, Andelain, Garcia-Caraballo, Sonia, Grundy, Luke, Harrington, Ann Chrystine, Inserra, Marco C, Israel, Mark R, Keramidas, Angelo, Lewis, Richard J, Maddern, Jessica, Rychkov, Grigori Y, Vetter, Irina, Zimmermann, Katharina   +15 more
core   +4 more sources

Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation

Nutrients
(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract.
N. Choi, Woogyun Choi, Jong-Hwan Lee, Joon Park, Y. Kim, Raju Das, J. Woo, B. Kim   +7 more
semanticscholar   +1 more source

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

Science, 2019
Targeting sodium channels Voltage-gated sodium (Nav) channels have been implicated in cardiac and neurological disorders. There are many subtypes of these channels, making it challenging to develop specific therapeutics.
Huaizong Shen, Dongliang Liu, Kun Wu, Jianlin Lei, N. Yan   +4 more
semanticscholar   +1 more source