Results 111 to 120 of about 9,275 (242)

Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7

The Journal of General Physiology, 2023
Mutations in the voltage-gated sodium channel NaV1.7 cause the chronic pain syndrome, inherited erythromelalgia. Structures of bacterial sodium channel NaVAb with these mutations revealed changes that would enhance the outward movement of the gating ...
G. Wisedchaisri, Tamer M. Gamal El-Din, Natasha M Powell, Ning Zheng, W. Catterall   +4 more
semanticscholar   +1 more source

Aberrant Molecular Myelin Architecture in Charcot–Marie–Tooth Disease Type 1A and Hereditary Neuropathy With Liability to Pressure Palsies

Glia, Volume 74, Issue 2, February 2026.
PMP22 copy number variation disrupts myelin architecture at SLIs and Nodes of Ranvier. Adherens junction and axoglial domain defects are often more severe in CMT1A than HNPP. Findings support PMP22 functioning as a structural organizer of myelin. ABSTRACT Charcot–Marie–Tooth Disease Type 1A (CMT1A) and Hereditary Neuropathy with Liability to Pressure ...
Kathryn R. Moss, Marvis A. Arowolo, Dave R. Gutierrez, Ahmet Höke   +3 more
wiley   +1 more source

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]

Wellcome Open Research, 2018
Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state.
Vanessa Pereira, Queensta Millet, Jose Aramburu, Cristina Lopez-Rodriguez, Claire Gaveriaux-Ruff, John N. Wood   +5 more
doaj   +1 more source

Update of the statement on safety of cannabidiol as a novel food

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract During the assessment of cannabidiol (CBD) as a novel food, in 2022 the NDA Panel identified significant data gaps. Concerns focused on potential adverse effects on the liver, gastrointestinal tract, endocrine, nervous and reproductive systems.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Francesco Cubadda, Helle Katrine Knutsen, Harry J. McArdle, Peter Moldeus, Monika Neuhäuser‐Berthold, Josef Rudolf Schlatter, Alexandros Siskos, Viviana Trezza, Océane Albert, Elisa Beneventi, Irene Nuin Garciarena, George E. N. Kass, Marcello Laganaro, Annamaria Rossi, Alejandra Muñoz, Areti Favata, Anna Maria Pieger, Maura Magani, Karen Ildico Hirsch‐Ernst   +33 more
wiley   +1 more source

Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods [PDF]

, 2017
Peer reviewedPublisher ...
EFSA Panel on Contaminants in the Food Chain (CONTAM)
core   +1 more source

A Novel Antigen Design Strategy to Isolate Single‐Domain Antibodies that Target Human Nav1.7 and Reduce Pain in Animal Models

Advancement of science
Genetic studies have identified the voltage‐gated sodium channel 1.7 (Nav1.7) as pain target. Due to the ineffectiveness of small molecules and monoclonal antibodies as therapeutics for pain, single‐domain antibodies (VHHs) are developed against the ...
Marzia Martina, Umberto Banderali, Alvaro Yogi, Mehdi Arbabi Ghahroudi, Hong Liu, T. Sulea, Yves Durocher, G. Hussack, H. van Faassen, Balu Chakravarty, Qing Yan Liu, Umar Iqbal, Binbing Ling, Etienne Lessard, J. Sheff, Anna C Robotham, Debbie Callaghan, Maria Moreno, Tanya Comas, Dao Ly, Danica B. Stanimirovic   +20 more
semanticscholar   +1 more source

Rethinking Strategies for a Pharmaceutical Approach to Pain Related to Connective Tissue–Related Raynaud Phenomenon in the United States

Arthritis Care &Research, Volume 78, Issue 1, Page 106-112, January 2026.
Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Tracy M. Frech, Charles G. Frech, W. David Merryman, Andrew Sternlicht, Justin Baba   +4 more
wiley   +1 more source

Tailoring μ-Conotoxin-KIIIA to Selectively Inhibit NaV1.7 [PDF]

Biophysical Journal, 2012
Voltage-gated sodium(NaV) channels are critical in initiating and propagating nerve impulses in a variety of tissues including, skeletal(NaV1.4) and cardiac(NaV1.5) muscle, brain(NaV1.2), and peripheral nerve(NaV1.7). Of special interest as a potential drug target is NaV1.7, which mediates propagation of pain signals from receptors to the CNS ...
McArthur, Jeff R., Singh, Gurpreet, McMaster, Denis, Winkfein, Robert, Tieleman, D. Peter, French, Robert J.   +5 more
openaire   +1 more source

Ion channel recordings on an injection-molded polymer chip [PDF]

, 2013
In this paper, we demonstrate recordings of the ion channel activity across the cell membrane in a biological cell by employing the so-called patch clamping technique on an injection-molded polymer microfluidic device.
Christensen, Mette Thylstrup, Christiansen, Thomas Lehrmann, Friis, Søren, Garnæs, Jørgen, Kutchinsky, Jonatan, Matteucci, Marco, Taboryski, Rafael, Tanzi, Simone, Wilson, Sandra   +8 more
core   +1 more source

Comparison of Nocifensive Behavior in NaV1.7–, NaV1.8–, and NaV1.9–Channelrhodopsin‐2 Mice by Selective Optogenetic Activation of Targeted Sodium Channel Subtype‐Expressing Afferents

Journal of Neuroscience Research
Voltage‐gated sodium channels, including NaV1.7, NaV1.8, and NaV1.9, play important roles in pain transmission and chronic pain development. However, the specific mechanisms of their action remain unclear, highlighting the need for in vivo stimulation ...
Toyoaki Maruta, Satoshi Kouroki, Mio Kurogi, K. Hidaka, Tomohiro Koshida, Ayako Miura, Hikaru Nakagawa, Toshihiko Yanagita, Ryu Takeya, Isao Tsuneyoshi   +9 more
semanticscholar   +1 more source