Results 121 to 130 of about 9,275 (242)

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

The Role of Neuro‐Immune Regulation in the Pathogenesis of Psoriasis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Psoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic ...
Xin Liu, Mingyu Yu, Pan Zou, Suwen Liu, Jian Jiang, Liyang Ge, Su Jiang, Jingyu Zhang, Xin Wang, Hongxiang Chen, Poorani Gurumallesh Prabu   +10 more
wiley   +1 more source

Two Novel Peptide Toxins from the Spider Cyriopagopus longipes Inhibit Tetrodotoxin-Sensitive Sodium Channels

Toxins, 2020
Sodium channels play a critical role in the generation and propagation of action potentials in excitable tissues, such as nerves, cardiac muscle, and skeletal muscle, and are the primary targets of toxins found in animal venoms.
Qingfeng Zhang, Yuxin Si, Li Yang, Li Wang, Shuijiao Peng, Yiming Chen, Minzhi Chen, Xi Zhou, Zhonghua Liu   +8 more
doaj   +1 more source

NaV1.7 targeted fluorescence imaging agents for nerve identification during intraoperative procedures

bioRxiv
Surgeries and trauma result in traumatic and iatrogenic nerve damage that can result in a debilitating condition that approximately affects 189 million individuals worldwide.
Junior Gonzales, D. Adilbay, Paula Demétrio de Souza França, R. Artschwager, C. Y. Chow, Tara Viray, Delissa S. Johnson, Yan Jiang, Snehal G Patel, I. Ganly, Christina I. Schroeder, Jason S. Lewis, Glenn F. King, Thomas Reiner, N. Pillarsetty   +14 more
semanticscholar   +1 more source

Neuroblastoma: Anti‐Invasive Effects of Tetracaine In Vitro*

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Ece Selçuk, David S. Silcock, Amanda Foust, Vicky Bousgouni, Mar Arias‐Garcia, Chris Bakal, Mustafa B. A. Djamgoz, Pinar Uysal‐Onganer   +7 more
wiley   +1 more source

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

Sensory Neuroscience, Volume 1, Issue 3, December 2025.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan, Avanthika Nityanand, Anjali Pandit, Vaishnavi Gururajan   +3 more
wiley   +1 more source

β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells

Frontiers in Cellular Neuroscience, 2013
Voltage-gated sodium channels (Navs) are glycoproteins composed of a pore-forming α-subunit and associated β-subunits that regulate Nav α-subunit plasma membrane density and biophysical properties. Glycosylation of the Nav α-subunit also directly affects
Cedric James Laedermann, Ninda eSyam, Isabelle eDecosterd, Hugues eAbriel   +3 more
doaj   +1 more source

Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels

Nature Communications, 2020
Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans. Here the authors found that activation of Nav1.9 can restore nociception in Nav1.7 knockout mice, revealed by a venom-derived peptide as a probe.
Xi Zhou, Tingbin Ma, Luyao Yang, Shuijiao Peng, Lulu Li, Zhouquan Wang, Zhen Xiao, Qingfeng Zhang, Li Wang, Yazhou Huang, Minzhi Chen, Songping Liang, Xianwei Zhang, Jing Yu Liu, Zhonghua Liu   +14 more
doaj   +1 more source

Novel SCN9A mutations underlying extreme pain phenotypes: unexpected electrophysiological and clinical phenotype correlations. [PDF]

, 2015
The importance of NaV1.7 (encoded by SCN9A) in the regulation of pain sensing is exemplified by the heterogeneity of clinical phenotypes associated with its mutation.
Cox, James J, Emery, Edward C, Gribble, Fiona M, Habib, Abdella M, Nicholas, Adeline K, Reimann, Frank, Woods, C Geoffrey   +6 more
core   +3 more sources

The pain target NaV1.7 is expressed late during human iPS cell differentiation into sensory neurons as determined in high-resolution imaging

Pflügers Archiv: European Journal of Physiology
Human-induced pluripotent stem cells (iPS cells) are efficiently differentiated into sensory neurons. These cells express the voltage-gated sodium channel NaV1.7, which is a validated pain target.
Yi Liu, Rachna Balaji, M. A. D. de Toledo, Sabrina Ernst, P. Hautvast, A. B. Kesdoğan, Jannis Körner, Martin Zenke, Anika Neureiter, Angelika Lampert   +9 more
semanticscholar   +1 more source