Results 131 to 140 of about 9,275 (242)

The Concise Guide to PHARMACOLOGY 2025/26: Ion channels

British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Jörg Striessnig, Alasdair J. Gibb, Alistair A. Mathie, Emma L. Veale, Eamonn Kelly, Chloe J. Peach, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, David J. Beech, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Han Chow Chua, Alex C. Conner, Henry Danahay, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Wei Fang, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, George K. Chandy, Mohammad‐Reza Ghovanloo, Steve A. N. Goldstein, Martin Gosling, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Tim G. Hales, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Rian W. Manville, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Pérez‐Reyes, Leigh D. Plant, Stephan A. Pless, Lachlan D. Rash, Dejian Ren, Hussein N. Rubaiy, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Paolo Tammaro, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Paola Vergani, Joris Vriens, Stephen G. Waxman, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +86 more
wiley   +1 more source

Vector‐mediated release of GABA attenuates pain‐related behaviors and reduces Na V 1.7 in DRG neurons [PDF]

, 2011
Pain is a common and debilitating accompaniment of neuropathy that occurs as a complication of diabetes. In the current study, we examined the effect of continuous release of gamma amino butyric acid (GABA), achieved by gene transfer of glutamic acid ...
Baron, Black, Castro-Lopes, Castro-Lopes, Chattopadhyay, Chattopadhyay, Coull, Cox, Cummins, David J. Finkl, Devor, Dib-Hajj, Dirig, Drenth, Eaton, Ekberg, Engle, Finnerup, Glorioso, Goss, Goss, Hao, Hao, Hao, Hargreaves, Hong, Hong, Hwang, Ibuki, Jolivalt, Lai, Lee, Liu, Liu, Malcangio, Malcangio, Mantyh, Marina Mata, Mata, Misawa, Moore, Munmun Chattopadhyay, Ong, Randall, Rho, Robinson, Shibuya, Smith, Sukhotinsky, Tavakoli, Wilson-Gerwing, Wolfe, Wolfe, Wolfe, Yang, Zhang   +55 more
core   +1 more source

Morpho‐Histo‐Cytological Evaluation of Oral Tissues in Burning Mouth Syndrome: A Systematic Review

Journal of Oral Rehabilitation, Volume 52, Issue 12, Page 2449-2480, December 2025.
This systematic review on Burning Mouth Syndrome (BMS) included 14 studies that examined histological changes. 12 studies used incisional biopsies and 2 used exfoliative cytology. Histology and molecular biology techniques were used to assess morphological, phenotypical and genomic changes in oral tissues, primarily from the tongue.
André Luís Porporatti, Ângela Graciela Deliga Schroder, Ashley Lebel, Nathan Moreau, Annabelle Réaux‐Le Goazigo, Ihsène Taïhi, Heike Rittner, Tara Renton, Yves Boucher   +8 more
wiley   +1 more source

Autonomic Dysfunction Linked to Inhibition of the Nav1.7 Sodium Channel

Circulation
uman genetic phenotypes associated with loss or gain of function implicate the Na v 1.7 channel as a promising target for novel analgesics. 1,2 However, the expression of Na V 1.7 on autonomic afferent c-type fibers, on sympathetic efferent ...
Chris Regan, Pierre Morissette, Richard L. Kraus, Erjia Wang, Leticia Arrington, Marissa Vavrek, Jan de Hoon, M. Depré, Thomas Lodeweyck, Ignace Demeyer, T. Laethem, Aubrey Stoch, Arie Struyk   +12 more
semanticscholar   +1 more source

Fluorescence Guided Surgery in Gastric Cancer: What Do We Have and What Can We Do?

Annals of Gastroenterological Surgery, Volume 9, Issue 6, Page 1137-1143, November 2025.
ABSTRACT Background and Objective Fluorescence imaging has emerged as a valuable adjunct in gastric surgery, enhancing resection precision and oncologic outcomes. However, the use of indocyanine green (ICG) remains controversial due to uncertainties in efficacy and administration. A lack of standardized protocols persists.
Chun Zhuang, Han‐Kwang Yang
wiley   +1 more source

Analgesic treatment of ciguatoxin-induced cold allodynia [PDF]

, 2013
Ciguatera, the most common form of nonbacterial ichthyosarcotoxism, is caused by consumption of fish that have bioaccumulated the polyether sodium channel activator ciguatoxin.
Cabot, Peter J., Collins, Lindon S., Deuis, Jennifer R., Inserra, Marco C., Lewis, Richard J., Namer, Barbara, Reeh, Peter W., Vetter, Irina, Zimmermann, Katharina   +8 more
core   +1 more source

Regulating neuronal excitability: The role of S-palmitoylation in NaV1.7 activity and voltage sensitivity

PNAS Nexus
S-palmitoylation, a reversible lipid post-translational modification, regulates the functions of numerous proteins. Voltage-gated sodium channels (NaVs), pivotal in action potential generation and propagation within cardiac cells and sensory neurons, can
Cheng Tang, Paz Duran, Aida Calderon-Rivera, Santiago Loya-López, Kimberly Gomez, S. Perez-Miller, R. Khanna   +6 more
semanticscholar   +1 more source

Patient Subgroups and Predictors of Improvement in Chronic Neuropathic Pain: A Trajectory‐Based Analysis

European Journal of Pain, Volume 29, Issue 10, November 2025.
ABSTRACT Background There is limited real‐world evidence on predictive factors for good outcomes in patients with chronic neuropathic pain (NP) treated in multidisciplinary tertiary care centres. This study aimed to identify subgroups of NP patients with similar pain trajectories and evaluate associated factors.
Xavier Moisset, M. Gabrielle Pagé, Bruno Pereira, Manon Choinière   +3 more
wiley   +1 more source

Sodium channel slow inactivation interferes with open channel block [PDF]

Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents.
A Kondratiev, A Lampert, A Lampert, A Taddese, AB Klinger, AC Errington, AM Rush, BW Jarecki, C Alzheimer, C Barbosa, C Nau, CC Kuo, EC Emery, IM Raman, IM Raman, J Magistretti, J Silva, JG Hoeijmakers, JH Chancey, JP Drenth, JP O’Reilly, JS Bant, JW Theile, JW Theile, M Eberhardt, M Estacion, M Estacion, PL Sheets, S Hebeisen, SD Dib-Hajj, SY Wang, SY Wang, TM Grieco, TP Harty, TR Cummins, TR Cummins, W Sandtner, X Cheng, X Cheng, X Cheng, Y Chen, Y Chen, Y Liu, ZM Khaliq   +43 more
core   +1 more source

Acyl Sulfonamides NaV1.7 Blockers Useful for the Treatment of Pain [PDF]

ACS Medicinal Chemistry Letters, 2018
Voltage gated sodium channels (NaV) are key proteins that control the flow of sodium ions across membranes in the majority of excitable cells. Their structural features can be divided into two distinct subunits. The alpha subunit is a single large protein that contains four functional domains that controls gating and conduction.
openaire   +2 more sources