Results 151 to 160 of about 9,275 (242)

Discovery of a Novel Nav1.7 Inhibitor From Cyriopagopus albostriatus Venom With Potent Analgesic Efficacy

Frontiers in Pharmacology, 2018
Spider venoms contain a vast array of bioactive peptides targeting ion channels. A large number of peptides have high potency and selectivity toward sodium channels.
Yunxiao Zhang, Dezheng Peng, Biao Huang, Qiuchu Yang, Qingfeng Zhang, Minzhi Chen, Mingqiang Rong, Zhonghua Liu   +7 more
doaj   +1 more source

Case Report and Literature Review: Interventional Management of Erythromelalgia. [PDF]

, 2019
Erythromelalgia is a rare and very difficult to treat pain syndrome that usually presents as severe bilateral burning pain in the extremities. Here we present a case of a 34-year-old female with erythromelalgia who we treated successfully with a lumbar ...
Chinn, Gregory, Guan, Zhonghui
core  

The road to evolution of ProTx2: how to be a subtype-specific inhibition of human Nav1.7

Frontiers in Pharmacology
The human voltage-gated sodium channel Nav1.7 is a widely proven target for analgesic drug studies. ProTx2, a 30-residue polypeptide from Peruvian green tarantula venom, shows high specificity to activity against human Nav1.7, suggesting its potential to
Fan Zhao, Yuanyuan Liu, Yiyu Liu, Qi Ye, Hongtao Yang, Mingze Gui, Yongbo Song   +6 more
doaj   +1 more source

Douleur chronique et mécanismes moléculaires [PDF]

, 2011
La douleur est définie par l'International association for the study of pain (IASP) comme une expérience sensorielle et émotionnelle désagréable, associée à une lésion tissulaire réelle ou à une lésion potentielle, ou décrite en des termes évoquant une ...
Schaller, M.
core  

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling [PDF]

, 2019
Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form
Cui, Jianmin, Gao, Yuan, Hou, Panpan, Shi, Jingyi, White, Kelli McFarland   +4 more
core   +1 more source

Carbamazepine in osteoarthritis treatment: A novel approach targeting Nav1.7 channels

World Journal of Orthopedics
Osteoarthritis (OA) presents a growing health concern, with substantial societal and healthcare burdens. Current management focuses on symptom relief, lacking disease-modifying options. Emerging research suggests the sodium channel Nav1.7 as a pivotal target in OA treatment.
Vaid, Rayyan, Sohail, Afra, Amir, Nabiha
openaire   +2 more sources

NaV1.7 (SCN9A) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

A transzmembrán jelátvitel integrált szabályozása: Ca2+-, K+-csatornák és interleukin-receptorok közötti interakciók = An integrated regulation of transmembrane signalling: interactions between Ca2+, K+ channels and interleukin receptors [PDF]

, 2009
Projektünk célkitűzése a transzmembrán jelátvitelben résztvevő egyes receptorok és ioncsatornák működésének multidiszciplináris megközelítése volt. Kimutattuk a TASK-3 K+-csatorna expresszióját és döntően mitokondriális lokalizációját melanoma malignum ...
Csernoch, László József, Damjanovich, Sándor, Dóczy-Bodnár, Andrea, Gáspár, Rezső, Kovács, László, Panyi, György, Rusznák, Zoltán, Szentesi, Péter Sándor, Szigeti, Gyula Péter, Szűcs, Géza, Varga, Zoltán, Vámosi, György   +11 more
core  

Nav1.7 (SCN9A) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Differential expression of slow and fast-repriming tetrodotoxin-sensitive sodium currents in dorsal root ganglion neurons

Frontiers in Molecular Neuroscience
Sodium channel Nav1.7 triggers the generation of nociceptive action potentials and is important in sending pain signals under physiological and pathological conditions.
Zhi-Yong Tan, Zhi-Yong Tan, Bin Wu, Bin Wu, Xiaolin Su, You Zhou, Yong-Hua Ji   +6 more
doaj   +1 more source