Results 41 to 50 of about 9,275 (242)

Nav1.7-P610T mutation in 2 siblings with persistent ocular pain after corneal axon transection: impaired slow-inactivation and hyperexcitable trigeminal neurons.

Journal of Neurophysiology, 2023
Despite extensive study, the mechanisms underlying pain after axonal injury remain incompletely understood. Pain after corneal refractive surgery provides a model, in humans, of the effect of injury to trigeminal afferent nerves.
Mohammad-Reza Ghovanloo, Philip R. Effraim, Jun-Hui Yuan, Betsy R. Schulman, D. Jacobs, S. Dib-Hajj, S. Waxman   +6 more
semanticscholar   +1 more source

Intranasal CRMP2-Ubc9 Inhibitor Regulates NaV1.7 to Alleviate Trigeminal Neuropathic Pain

bioRxiv, 2023
Dysregulation of voltage-gated sodium NaV1.7 channels in sensory neurons contributes to chronic pain conditions, including trigeminal neuropathic pain.
Santiago Loya-López, Heather N. Allen, Paz Duran, Aida Calderon-Rivera, Kimberly Gomez, Upasana Kumar, Rory Shields, Rui Zeng, Akshat Dwivedi, Saumya Saurabh, Olga A. Korczeniewska, R. Khanna   +11 more
semanticscholar   +2 more sources

Progesterone Attenuates Allodynia of Inflamed Temporomandibular Joint through Modulating Voltage-Gated Sodium Channel 1.7 in Trigeminal Ganglion

Pain Research and Management, 2020
Background. Women with temporomandibular disorders (TMDs) experience some amelioration of pain during pregnancy. Progesterone increases dramatically and steadily during pregnancy. Sodium channel 1.7 (Nav1.7) plays a prominent role in pain perceptions, as
Rui-Yun Bi, Xiao-Yu Zhang, Peng Zhang, Yun Ding, Ye-Hua Gan   +4 more
doaj   +1 more source

An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]

, 2015
Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro, Onwuli, Donatus O.   +1 more
core   +1 more source

Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine. [PDF]

PLoS ONE, 2015
Mexiletine and lidocaine are widely used class IB anti-arrhythmic drugs that are considered to act by blocking voltage-gated open sodium currents for treatment of ventricular arrhythmias and relief of pain.
Ying Wang, Jianxun Mi, Ka Lu, Yanxin Lu, KeWei Wang   +4 more
doaj   +1 more source

Nav1.7 withholds its pain potential [PDF]

Nature Reviews Drug Discovery, 2019
Despite compelling genetic validation, drug developers are struggling to unlock the therapeutic promise of the Nav1.7 sodium channel as a pain target. Despite compelling genetic validation, drug developers are struggling to unlock the therapeutic promise of the Nav1.7 sodium channel as a pain target.
openaire   +1 more source

Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats

Journal of Neuroinflammation, 2018
Background The proinflammatory cytokine interleukin-1β (IL-1β) drives pain by inducing the expression of inflammatory mediators; however, its ability to regulate sodium channel 1.7 (Nav1.7), a key driver of temporomandibular joint (TMJ) hypernociception,
Peng Zhang, Rui-Yun Bi, Ye-Hua Gan
doaj   +1 more source

Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: The trigeminal neuralgia experience [PDF]

, 2018
Background: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia.
Bendtsen, Lars, Cruccu, Giorgio, Di Stefano, Giulia, Ettlin, Dominik A., Maarbjerg, Stine, Morisset, Valerie, Obermann, Mark, Palmer, Joanne, Steiner, Deb, Tate, Simon, Zakrzewska, Joanna M.   +10 more
core   +4 more sources

Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model

BMC Anesthesiology, 2017
Background Persistent post-surgical pain is a difficult clinical problem. In this study, we intend to explore the mechanism underlying the persistent post-surgical pain in SMIR (skin/muscle incision and retraction) rats.
Zhisong Li, Yaru Li, Jing Cao, Xuemin Han, Weihua Cai, Weidong Zang, Jitian Xu, Wei Zhang   +7 more
doaj   +1 more source

Lacosamide Inhibition of NaV1.7 Channels Depends on its Interaction With the Voltage Sensor Domain and the Channel Pore

Frontiers in Pharmacology, 2021
Lacosamide, developed as an anti-epileptic drug, has been used for the treatment of pain. Unlike typical anticonvulsants and local anesthetics which enhance fast-inactivation and bind within the pore of sodium channels, lacosamide enhances slow ...
Julie I. R. Labau, Julie I. R. Labau, Julie I. R. Labau, Julie I. R. Labau, Julie I. R. Labau, Matthew Alsaloum, Matthew Alsaloum, Matthew Alsaloum, Matthew Alsaloum, Matthew Alsaloum, Mark Estacion, Mark Estacion, Mark Estacion, Brian Tanaka, Brian Tanaka, Brian Tanaka, Fadia B. Dib-Hajj, Fadia B. Dib-Hajj, Fadia B. Dib-Hajj, Giuseppe Lauria, Giuseppe Lauria, Hubert J. M. Smeets, Hubert J. M. Smeets, Catharina G. Faber, Sulayman Dib-Hajj, Sulayman Dib-Hajj, Sulayman Dib-Hajj, Stephen G. Waxman, Stephen G. Waxman, Stephen G. Waxman   +29 more
doaj   +1 more source