Results 61 to 70 of about 9,275 (242)

Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain. [PDF]

PLoS ONE, 2015
While genetic evidence shows that the Nav1.7 voltage-gated sodium ion channel is a key regulator of pain, it is unclear exactly how Nav1.7 governs neuronal firing and what biophysical, physiological, and distribution properties of a pharmacological Nav1 ...
David J Matson, Darryl T Hamamoto, Howard Bregman, Melanie Cooke, Erin F DiMauro, Liyue Huang, Danielle Johnson, Xingwen Li, Jeff McDermott, Carrie Morgan, Ben Wilenkin, Annika B Malmberg, Stefan I McDonough, Donald A Simone   +13 more
doaj   +1 more source

NaV1.7 channels in bronchial smooth muscle

, 2022
Supplementary data for "Functional expression of NaV1.7 channels in freshly dispersed mouse bronchial smooth muscle cells" by Mathews et al. AJP Cell.
Thornbury, keith, Matthews, Ruth, Bradley, Eamonn, Griffin, Caoimhin S., Lim, Xin Rui, Mullins, Nicolas, Hollywod, Mark, Lundy, Fionnuala T, McGarvey, Lorcan, sergeant, gerard   +9 more
openaire   +1 more source

Selective optogenetic activation of NaV1.7–expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli

PLoS ONE, 2022
In small and large spinal dorsal root ganglion neurons, subtypes of voltage-gated sodium channels, such as NaV1.7, NaV1.8, and NaV1.9 are expressed with characteristically localized and may play different roles in pain transmission and intractable pain ...
Toyoaki Maruta, Kotaro Hidaka, Satoshi Kouroki, Tomohiro Koshida, Mio Kurogi, Yohko Kage, Seiya Mizuno, Tetsuro Shirasaka, Toshihiko Yanagita, Satoru Takahashi, Ryu Takeya, Isao Tsuneyoshi   +11 more
doaj   +2 more sources

Mining the Nav1.7 interactome: Opportunities for chronic pain therapeutics [PDF]

Biochemical Pharmacology, 2019
The peripherally expressed voltage-gated sodium NaV1.7 (gene SCN9A) channel boosts small stimuli to initiate firing of pain-signaling dorsal root ganglia (DRG) neurons and facilitates neurotransmitter release at the first synapse within the spinal cord. Mutations in SCN9A produce distinct human pain syndromes.
Lindsey A. Chew, Shreya S. Bellampalli, Erik T. Dustrude, Rajesh Khanna   +3 more
openaire   +2 more sources

Mechanisms Underlying Gastrodin Alleviating Vincristine-Induced Peripheral Neuropathic Pain

Frontiers in Pharmacology, 2021
Gastrodin (GAS) is the main bioactive ingredient of Gastrodia, a famous Chinese herbal medicine widely used as an analgesic, but the underlying analgesic mechanism is still unclear.
Xiangyu Wang, Boxuan Zhang, Xuedong Li, Xuedong Li, Xingang Liu, Songsong Wang, Yuan Xie, Jialing Pi, Zhiyuan Yang, Jincan Li, Qingzhong Jia, Qingzhong Jia, Qingzhong Jia, Qingzhong Jia, Yang Zhang, Yang Zhang   +15 more
doaj   +1 more source

Voltage-gated sodium channels: new targets in cancer therapy? [PDF]

, 2006
Early detection and treatment of cancers have increased survival and improved clinical outcome. The development of metastases is often associated with a poor prognostic of survival. Finding early markers of metastasis and developing new therapies against
Besson, Pierre, Le Guennec, Jean-Yves, Potier, Marie, Roger, Sébastien, Vandier, Christophe   +4 more
core   +2 more sources

Voltage-Gated Sodium Channel NaV1.7 Inhibitors with Potent Anticancer Activities in Medullary Thyroid Cancer Cells

Cancers, 2023
Simple Summary Despite the recent advances in the diagnosis and treatment of medullary thyroid cancer (MTC), it remains an understudied cancer type and continues to disproportionately contribute to thyroid-cancer-related mortality. In this manuscript, we
P. Pukkanasut, J. Whitt, R. Guenter, Shannon E Lynch, Carlos A. Gallegos, M. J. Rosendo-Pineda, J. Gomora, Herbert Chen, Diana Lin, A. Sorace, R. Jaskula-Sztul, S. Velu   +11 more
semanticscholar   +1 more source

Functional effects of schizophrenia-linked genetic variants on intrinsic single-neuron excitability: A modeling study

, 2015
Background: Recent genome-wide association studies (GWAS) have identified a large number of genetic risk factors for schizophrenia (SCZ) featuring ion channels and calcium transporters.
Andreassen, Ole A., Bettella, Francesco, Dale, Anders M., Devor, Anna, Djurovic, Srdjan, Einevoll, Gaute T., Halnes, Geir, Mäki-Marttunen, Tuomo, Wang, Yunpeng, Witoelar, Aree   +9 more
core   +2 more sources

Therapeutic opportunities for targeting cold pain pathways [PDF]

, 2015
Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive.
Lewis, Richard J., Vetter, Irina, Yin, Kathleen, Zimmermann, Katharina   +3 more
core   +1 more source

Cutaneous nerve fiber and peripheral Nav1.7 assessment in a large cohort of patients with postherpetic neuralgia

Pain, 2023
Supplemental Digital Content is Available in the Text. Bilateral skin biopsies from a large cohort of patients with postherpetic neuralgia (PHN) showed no correlation of intraepidermal nerve fiber density with baseline pain and confirmed that concurrent ...
Michael Fetell, M. Sendel, Thomas Li, L. Marinelli, J. Vollert, Elizaeth Ruggerio, George Houk, Marilyn Dockum, P. Albrecht, F. Rice, R. Baron   +10 more
semanticscholar   +1 more source