Results 71 to 80 of about 9,275 (242)

The Two Sides of NaV1.7: Painful and Painless Channelopathies [PDF]

Neuron, 2019
Sodium channel NaV1.7 is a major target in pain research, largely because of genetic validation. In this issue of Neuron, McDermott et al. (2019) now present a comprehensive assessment of congenital pain insensitivity due to NaV1.7 loss of function. This work and studies on NaV1.7 gain of function raise important questions about how channelopathies ...
Stephen G, Waxman, Sulayman D, Dib-Hajj
openaire   +2 more sources

Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V. [PDF]

PLoS ONE, 2018
Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series ...
Bryan D Moyer, Justin K Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau, John B Jordan, Josie H Lee, Dong Liu, Jason Long, Kelvin Sham, Licheng Shi, Reto Stöcklin, Bin Wu, Ruoyuan Yin, Violeta Yu, Anruo Zou, Kaustav Biswas, Les P Miranda   +17 more
doaj   +1 more source

Nerve growth factor enhances voltage-gated Na+ channel activity and transwell migration in Mat-LyLu rat prostate cancer cell line [PDF]

, 2007
The highly dynamic nature of voltage-gated Na+ channel (VGSC) expression and its controlling mechanism(s) are not well understood. In this study, we investigated the possible involvement of nerve growth factor (NGF) in regulating VGSC activity in the ...
Brackenbury, William J., Djamgoz, Mustafa B. A.   +1 more
core   +1 more source

Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Nav1.7

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Nav1.7 has been targeted for pain management for its well-established role in pain sensation. Hundreds of mutations of Nav1.7 have been found in patients with pain disorders.
Gaoxingyu Huang, Qiurong Wu, Zhangqiang Li, Xueqin Jin, Xiaoshuang Huang, Tong Wu, Xiaojing Pan, N. Yan   +7 more
semanticscholar   +1 more source

β1 subunit stabilises sodium channel Nav1.7 against mechanical stress [PDF]

The Journal of Physiology, 2018
Key points The voltage‐gated sodium channel Nav1.7 is a key player in neuronal excitability and pain signalling. In addition to voltage sensing, the channel is also modulated by mechanical stress. Using whole‐cell patch‐clamp experiments, we discovered that the sodium channel subunit β1 is able to prevent the impact of mechanical stress on Nav1.7.
Jannis Körner, Jannis Meents, Jan‐Philipp Machtens, Angelika Lampert   +3 more
openaire   +2 more sources

Newly Discovered Action of HpTx3 from Venom of Heteropoda venatoria on Na_v1.7 and Its Pharmacological Implications in Analgesia

Toxins, 2019
It has been reported that Heteropodatoxin3 (HpTx3), a peptidic neurotoxin purified from the venom of the spider species Heteropoda venatoria, could inhibit Kv4.2 channels.
Xinzhou Wu, Zhouquan Wang, Yu Chen, Dehong Xu, Peng Zhang, Xianchun Wang   +5 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

eLife, 2023
The voltage-gated sodium (NaV) channel NaV1.7 has been identified as a potential novel analgesic target due to its involvement in human pain syndromes. However, clinically available NaV channel-blocking drugs are not selective among the nine NaV channel ...
Marc Kschonsak, Christine C Jao, Christopher P Arthur, Alexis L Rohou, Philippe Bergeron, Daniel F Ortwine, Steven J McKerrall, David H Hackos, Lunbin Deng, Jun Chen, Tianbo Li, Peter S Dragovich, Matthew Volgraf, Matthew R Wright, Jian Payandeh, Claudio Ciferri, John C Tellis   +16 more
doaj   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7 [PDF]

Neuron, 2017
The current knowledge about heat nociception is mainly confined to the thermosensors, including the transient receptor potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG). However, the loss of thermosensors only partially impairs heat nociception, suggesting the existence of undiscovered mechanisms.
Liu, Yang, Fei, Dong, Qing, Yang, Pai-Feng, Yang, Ruiqi, Wu, Qing-Feng, Wu, Dan, Wu, Chang-Lin, Li, Yan-Qing, Zhong, Ying-Jin, Lu, Xiaoyang, Cheng, Fu-Qiang, Xu, Limin, Chen, Lan, Bao, Xu, Zhang   +14 more
openaire   +2 more sources