Results 81 to 90 of about 9,275 (242)

Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia [PDF]

, 2017
Automated patch clamp (APC) technology was first developed at the turn of the millennium. The increased throughput it afforded promised a new paradigm in ion channel recordings: it offered the potential to overcome the time-consuming, low-throughput ...
Alexander, Alexander, Alexander, Alexander, Alexandrou, Arias, Asmild, Bagal, Becker, Bridgland-Taylor, Brinkwirth, Brüggemann, Cao, Castle, Chambard, Chambers, Dale, Danker, Deuis, Dunlop, Dunlop, Enna, Estacion, Fertig, Finkel, Friis, Gilbert, Gillie, Golden, Hamill, Hao, Haraguchi, Haythornthwaite, Ji, Kahle, Kao, Kauthale, Klement, Klint, Knabl, Kornecook, Kumar, Kuryshev, Lepple-Wienhues, Lin, Mathes, Mathes, Mathie, Miller, Milligan, Obergrussberger, Obergrussberger, Papakosta, Payne, Perkel, Sakmann, Sauter, Scheel, Schroeder, Shcherbatko, Shcherbatko, Sorota, Southan, Southan, Spencer, Stannard, Stoelzle, Swensen, Tao, Terstappen, Tibbs, Trivedi, Vasilyev, Windley, Xie, Xu, Xu   +76 more
core   +1 more source

Ultrasound‐Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu, Li‐Juan Liu, Fa‐Ming Xu, Xiang‐Yu Fang   +3 more
wiley   +1 more source

Temperature Dependence of Erythromelalgia Mutation L858F in Sodium Channel Nav1.7 [PDF]

Molecular Pain, 2007
Background: The disabling chronic pain syndrome erythromelalgia (also termed erythermalgia) is characterized by attacks of burning pain in the extremities induced by warmth. Pharmacological treatment is often ineffective, but the pain can be alleviated by cooling of the limbs.
Rush Anthony M, Lampert Angelika, Han Chongyang, Dib-Hajj Sulayman D, Wang Xiaoliang, Yang Yong, Waxman Stephen G   +6 more
openaire   +3 more sources

Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain

Toxins, 2018
Jingzhaotoxin-34 (JZTX-34) is a selective inhibitor of tetrodotoxin-sensitive (TTX-S) sodium channels. In this study, we found that JZTX-34 selectively acted on Nav1.7 with little effect on other sodium channel subtypes including Nav1.5.
Xiongzhi Zeng, Pengpeng Li, Bo Chen, Juan Huang, Ren Lai, Jingze Liu, Mingqiang Rong   +6 more
doaj   +1 more source

Neanderthal introgression in SCN9A impacts mechanical pain sensitivity

Communications Biology, 2023
The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate ...
Pierre Faux, Li Ding, Luis Miguel Ramirez-Aristeguieta, J. Camilo Chacón-Duque, Maddalena Comini, Javier Mendoza-Revilla, Macarena Fuentes-Guajardo, Claudia Jaramillo, William Arias, Malena Hurtado, Valeria Villegas, Vanessa Granja, Rodrigo Barquera, Paola Everardo-Martínez, Mirsha Quinto-Sánchez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C. Silva de Cerqueira, Tábita Hünemeier, Virginia Ramallo, Rolando Gonzalez-José, Lavinia Schüler-Faccini, Maria-Cátira Bortolini, Victor Acuña-Alonzo, Samuel Canizales-Quinteros, Giovanni Poletti, Carla Gallo, Francisco Rothhammer, Winston Rojas, Annina B. Schmid, Kaustubh Adhikari, David L. Bennett, Andrés Ruiz-Linares   +32 more
doaj   +1 more source

Discordance between preclinical and clinical testing of NaV1.7-selective inhibitors for pain

Pain
The voltage-gated sodium channel NaV1.7 plays an important role in pain processing according to genetic data. Those data made NaV1.7 a popular drug target, especially since its relatively selective expression in nociceptors promised pain relief without ...
Jane Yang, Yu-Feng Xie, R. Smith, Stéphanie Ratté, Steven A. Prescott   +4 more
semanticscholar   +1 more source

Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Nav1.7 and Nav1.5

Biomolecules & Therapeutics, 2023
Tramadol is an opioid analog used to treat chronic and acute pain. Intradermal injections of tramadol at hundreds of millimoles have been shown to produce a local anesthetic effect.
Chan-Su Bok, Ryeong-Eun Kim, Yong-Yeon Cho, Jin-Sung Choi   +3 more
semanticscholar   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Size Matters: Erythromelalgia Mutation S241T in Nav1.7 Alters Channel Gating [PDF]

Journal of Biological Chemistry, 2006
The Nav1.7 sodium channel is preferentially expressed in most nociceptive dorsal root ganglion neurons and in sympathetic neurons. Inherited erythromelalgia (IEM, also known as erythermalgia), an autosomal dominant neuropathy characterized by burning pain in the extremities in response to mild warmth, has been linked to mutations in Nav1.7. Recently, a
Angelika, Lampert, Sulayman D, Dib-Hajj, Lynda, Tyrrell, Stephen G, Waxman   +3 more
openaire   +2 more sources

Pathogenetic role of the pain threshold Hypothetical therapeutic perspectives based on the use of drugs to elevate it

Pathos, 2023
The pain threshold determines the extent of pain perception, and in some cases, its manifestation. Therefore, it is important in certain situations to increase the pain threshold. Measuring the pain threshold is challenging due to its approximate nature.
Guido Orlandini
doaj