Results 51 to 60 of about 149,617 (194)

Investigating blood–brain barrier penetration and neurotoxicity of natural products for central nervous system drug development

Scientific Reports
Natural Products (NPs) are increasingly utilized worldwide for their potential therapeutic benefits, including central nervous system (CNS) disorders.
Rintaro Kato, Li Zhang, Nivedita Kinatukara, Ruili Huang, Abhinav Asthana, Claire Weber, Menghang Xia, Xin Xu, Pranav Shah   +8 more
doaj   +1 more source

Comparative Assessment and High-Throughput Drug-Combination Profiling of TEAD-Palmitoylation Inhibitors in Hippo Pathway Deficient Mesothelioma

Pharmaceuticals, 2023
The hippo signaling pathway is a central tumor suppressor cascade frequently inactivated in selected human cancers, leading to the aberrant activation of TEAD transcription factors.
Lale Evsen, Patrick J. Morris, Craig J. Thomas, Michele Ceribelli   +3 more
doaj   +1 more source

A hopeful therapy for Niemann-Pick C diseases [PDF]

, 2017
Not abstract ...
Erickson, Robert P., Fiorenza, Maria Teresa   +1 more
core   +1 more source

2389

Journal of Clinical and Translational Science, 2017
OBJECTIVES/SPECIFIC AIMS: The goal of this abstract/presentation is to share lessons learned from participation in the NIH SBIR I-Corps Train-The-Trainer Program, discuss our experiences offering programs at our local institutions, and communicate our ...
Molly Wasko, Elaine Morrato, Nicholas Kenyon, Suhrud Rajguru, Bruce Conway, Sara Love, Nate Hafer, Pamela Bhatti, Jonathan Fay, Seth Zonies   +9 more
doaj   +1 more source

Telemedicine infectious diseases consultations and clinical outcomes: A systematic review [PDF]

, 2019
Background: Telemedicine use is increasing in many specialties, but its impact on clinical outcomes in infectious diseases has not been systematically reviewed.
Burnham, Jason P, Colditz, Graham A, Fritz, Stephanie A, Yaeger, Lauren H   +3 more
core   +2 more sources

A key role for leukemia inhibitory factor in C26 cancer cachexia [PDF]

, 2015
Cachexia is an exacerbating event in many types of cancer that is strongly associated with a poor prognosis. We have identified cytokine, signaling, and transcription factors that are required for cachexia in the mouse C26 colon carcinoma model of cancer.
Jackman, Robert W., Kandarian, Susan C., Seto, Danielle N.   +2 more
core   +1 more source

Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism

Scientific Reports
Hepatic clearance is crucial as it directly impacts drug exposure, efficacy, and safety. Cytochrome P450 (CYP450) enzymes play a pivotal role in drug metabolism and exhibit differences based on sex, species, and commercial liver microsome vendors.
Nivedita Kinatukara, Xin Xu, Pranav Shah
doaj   +1 more source

Hilbert-curve assisted structure embedding method

Journal of Cheminformatics
Motivation Chemical space embedding methods are widely utilized in various research settings for dimensional reduction, clustering and effective visualization. The maps generated by the embedding process can provide valuable insight to medicinal chemists
Gergely Zahoránszky-Kőhalmi, Kanny K. Wan, Alexander G. Godfrey   +2 more
doaj   +1 more source

The IDeaS initiative: pilot study to assess the impact of rare diseases on patients and healthcare systems

Orphanet Journal of Rare Diseases, 2021
Background Rare diseases (RD) are a diverse collection of more than 7–10,000 different disorders, most of which affect a small number of people per disease.
Ainslie Tisdale, Christine M. Cutillo, Ramaa Nathan, Pierantonio Russo, Bryan Laraway, Melissa Haendel, Douglas Nowak, Cindy Hasche, Chun-Hung Chan, Emily Griese, Hugh Dawkins, Oodaye Shukla, David A. Pearce, Joni L. Rutter, Anne R. Pariser   +14 more
doaj   +1 more source

Clinical pharmacology as a foundation for translational science. [PDF]

, 2011
The evolution of enabling technologies and their associated perspectives into molecular mechanisms underlying disease has extended beyond the abilities of scientific and clinical structures to advance their translation into new algorithms that improve ...
Hohl, R J., Kearns, G L., Swan, S J., Terzic, A, Waldman, Scott A.   +4 more
core   +2 more sources