Results 31 to 40 of about 150,411 (276)

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Electrical Discharges in Oil-Lubricated Rolling Contacts and Their Detection Using Electrostatic Sensing Technique

Sensors, 2022
The reliability of rolling element bearings has been substantially undermined by the presence of parasitic and stray currents. Electrical discharges can occur between the raceway and the rolling elements and it has been previously shown that these ...
Kamran Esmaeili, Ling Wang, Terry J. Harvey, Neil M. White, Walter Holweger   +4 more
doaj   +1 more source

Effects of dietary protein and fiber at breakfast on appetite, ad libitum energy intake at lunch, and neural responses to visual food stimuli in overweight adults [PDF]

, 2016
Increasing either protein or fiber at mealtimes has relatively modest effects on ingestive behavior. Whether protein and fiber have additive or interactive effects on ingestive behavior is not known.
Amankwaah, Akua F., Campbell, Wayne W., Chen, Ningning, Cornier, Marc-Andre, Kareken, David A., McCrory, Megan A., Sayer, R. Drew, Talavage, Thomas M., Tamer, Gregory G., Tregellas, Jason R., Wright, Amy J.   +10 more
core   +3 more sources

Precision information extraction for rare disease epidemiology at scale

Journal of Translational Medicine, 2023
Background The United Nations recently made a call to address the challenges of an estimated 300 million persons worldwide living with a rare disease through the collection, analysis, and dissemination of disaggregated data. Epidemiologic Information (EI)
William Z. Kariampuzha, Gioconda Alyea, Sue Qu, Jaleal Sanjak, Ewy Mathé, Eric Sid, Haley Chatelaine, Arjun Yadaw, Yanji Xu, Qian Zhu   +9 more
doaj   +1 more source

Disruptive Strategies for Removing Drug Discovery Bottlenecks [PDF]

, 2012
Drug Discovery is shifting focus from the industry to outside partners and in the process creating new bottlenecks, suggesting the need for a more disruptive overhaul.
Antony Williams, Chris Waller, Mary Bradley, Sean Ekins, Sean Ekins   +4 more
core   +2 more sources

A review of the validity of computerized neurocognitive assessment tools in mild traumatic brain injury assessment

Concussion, 2017
Computerized neurocognitive assessment tools (NCATs) offer potential advantages over traditional neuropsychological tests in postconcussion assessments. However, their psychometric properties and clinical utility are still questionable.
Jacques P Arrieux, Wesley R Cole, Angelica P Ahrens   +2 more
doaj   +1 more source

Functional brain region-specific neural spheroids for modeling neurological diseases and therapeutics screening

Communications Biology, 2023
3D spheroids have emerged as powerful drug discovery tools given their high-throughput screening (HTS) compatibility. Here, we describe a method for generating functional neural spheroids by cell-aggregation of differentiated human induced pluripotent ...
Caroline E. Strong, Jiajing Zhang, Martin Carrasco, Srikanya Kundu, Molly Boutin, Harshad D. Vishwasrao, Jiamin Liu, Angelica Medina, Yu-Chi Chen, Kelli Wilson, Emily M. Lee, Marc Ferrer   +11 more
doaj   +1 more source

Searching for a Needle in a Haystack: Cas9-Targeted Nanopore Sequencing and DNA Methylation Profiling of Full-Length Glutenin Genes in a Big Cereal Genome

Plants, 2021
Sequencing and epigenetic profiling of target genes in plants are important tasks with various applications ranging from marker design for plant breeding to the study of gene expression regulation.
Ilya Kirov, Ekaterina Polkhovskaya, Maxim Dudnikov, Pavel Merkulov, Anastasia Vlasova, Gennady Karlov, Alexander Soloviev   +6 more
doaj   +1 more source

Evaluating quality of life tools in North American patients with erythropoietic protoporphyria and X-linked protoporphyria. [PDF]

, 2019
BackgroundErythropoietic protoporphyria (EPP) and X-linked Protoporphyria (XLP) are rare photodermatoses presenting with severe phototoxicity. Although anecdotally, providers who treat EPP patients acknowledge their life-altering effects, tools that ...
Anderson, Karl E, Balwani, Manisha, Bissell, D Montgomery, Bloomer, Joseph, Bonkovsky, Herbert L, Desnick, Robert J, Naik, Hetanshi, Overbey, Jessica R, Phillips, John D, Singal, Ashwani, Wang, Bruce   +10 more
core   +1 more source

From scientific discovery to treatments for rare diseases – the view from the National Center for Advancing Translational Sciences – Office of Rare Diseases Research

Orphanet Journal of Rare Diseases, 2018
We now live in a time of unprecedented opportunities to turn scientific discoveries into better treatments for the estimated 30 million people in the US living with rare diseases.
Petra Kaufmann, Anne R. Pariser, Christopher Austin   +2 more
doaj   +1 more source