Results 11 to 20 of about 150,411 (276)

DEIA is essential to advance the goals of translational science: Perspectives from NCATS

Journal of Clinical and Translational Science, 2023
The National Center for Advancing Translational Science (NCATS) seeks to improve upon the translational process to advance research and treatment across all diseases and conditions and bring these interventions to all who need them. Addressing the racial/
Shadab F. Hussain, Amanda L. Vogel, Jessica M. Faupel-Badger, Linda Ho, Lameese D. Akacem, Krishna Balakrishnan, Rebekah Geiger, Rashmi Gopal-Srivastava, Brittany Haynes, Marcus G. Hodges, Tanetta Isler, Ewy A. Mathé, Leonie Misquitta, Karlie R. Sharma, Eric Sid, Jamie L. Zigterman, Penny W. Burgoon   +16 more
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Gene Therapy: The View from NCATS [PDF]

Human Gene Therapy, 2016
The National Center for Advancing Translational Sciences (NCATS) at the National Institutes of Health (NIH) was established in December 2011. NCATS mission is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of interventions that improve human health across a wide range of ...
Brooks, Philip J., Yang, N. Nora, Austin, Christopher P.   +2 more
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NCATS Inxight Drugs: a comprehensive and curated portal for translational research [PDF]

Nucleic Acids Research, 2021
Abstract The United States has a complex regulatory scheme for marketing drugs. Understanding drug regulatory status is a daunting task that requires integrating data from many sources from the United States Food and Drug Administration (FDA), US government publications, and other processes related to drug development.
Vishal B Siramshetty, Ivan Grishagin, Ðắc-Trung Nguyễn, Tyler Peryea, Yulia Skovpen, Oleg Stroganov, Daniel Katzel, Timothy Sheils, Ajit Jadhav, Ewy A Mathé, Noel T Southall   +10 more
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Innovation in Therapeutics Development at the NCATS [PDF]

Neuropsychopharmacology, 2013
Never before has there been such a sense of urgency to rethink the way in which therapeutics are discovered and developed. Drug development has grown less efficient with every passing year (http://www.phrma.org; Scannell et al, 2012), at the same time as fundamental understanding of human biology in health and disease has exploded.
Christine M, Colvis, Christopher P, Austin   +1 more
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Predicting liver cytosol stability of small molecules

Journal of Cheminformatics, 2020
Over the last few decades, chemists have become skilled at designing compounds that avoid cytochrome P (CYP) 450 mediated metabolism. Typical screening assays are performed in liver microsomal fractions and it is possible to overlook the contribution of ...
Pranav Shah, Vishal B. Siramshetty, Alexey V. Zakharov, Noel T. Southall, Xin Xu, Dac-Trung Nguyen   +5 more
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A public–private collaboration model for clinical innovation

Clinical and Translational Science, 2022
Launched in May 2012 as part of the New Therapeutic Uses program, the National Center for Advancing Translational Sciences (NCATS)’ National Institutes of Health (NIH)‐Industry Partnerships initiative fostered collaboration between pharmaceutical ...
Craig D. Wegner, Bobbie Ann Mount, Christine M. Colvis   +2 more
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Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria. [PDF]

, 2020
PurposeAcute intermittent porphyria (AIP) is a rare inborn error of heme biosynthesis characterized by life-threatening acute attacks. Few studies have assessed quality of life (QoL) in AIP and those that have had small sample sizes and used tools that ...
Anderson, Karl E, Balwani, Manisha, Bissell, D Montgomery, Bonkovsky, Herbert L, Desnick, Robert J, Erwin, Angelika, Keel, Siobán, Levy, Cynthia, McGuire, Brendan, Montgomery, Guy H, Naik, Hetanshi, Overbey, Jessica R, Phillips, John D, Wang, Bruce, Winkel, Gary   +14 more
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Scientific evidence based rare disease research discovery with research funding data in knowledge graph

Orphanet Journal of Rare Diseases, 2021
Background Limited knowledge and unclear underlying biology of many rare diseases pose significant challenges to patients, clinicians, and scientists. To address these challenges, there is an urgent need to inspire and encourage scientists to propose and
Qian Zhu, Ðắc-Trung Nguyễn, Timothy Sheils, Gioconda Alyea, Eric Sid, Yanji Xu, James Dickens, Ewy A. Mathé, Anne Pariser   +8 more
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Influence of White Etching Bands Formation on Integrity of Rolling Element Bearings

Tribology Online, 2023
The development of subsurface microstructural alterations known as dark etching regions (DERs) and white etching bands (WEBs) in rolling element bearings due to rolling contact fatigue have been investigated for the past eight decades, focusing on their ...
Mostafa El Laithy, Ling Wang, Terry J. Harvey, Bernd Vierneusel   +3 more
doaj   +1 more source

Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells

Scientific Reports, 2021
MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4+ T helper cells which are key players in autoimmune diseases.
Anju Singh, Myagmarjav Dashynam, Bryan Chim, Thelma M. Escobar, Xiuhuai Liu, Xin Hu, Samarjit Patnaik, Xin Xu, Noel Southall, Juan Marugan, Ajit Jadhav, Vanja Lazarevic, Stefan A. Muljo, Marc Ferrer   +13 more
doaj   +1 more source