Results 51 to 60 of about 150,411 (276)

NCATS Is Out of the Bag [PDF]

Cancer Discovery, 2012
Abstract NIH has officially launched the National Center for Advancing Translational Sciences, a “hub for catalyzing innovations in translational science.”
openaire   +1 more source

Integrative rare disease biomedical profile based network supporting drug repurposing or repositioning, a case study of glioblastoma

Orphanet Journal of Rare Diseases, 2023
Background Glioblastoma (GBM) is the most aggressive and common malignant primary brain tumor; however, treatment remains a significant challenge.
Erin McGowan, Jaleal Sanjak, Ewy A. Mathé, Qian Zhu   +3 more
doaj   +1 more source

Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform

Frontiers in Pharmacology, 2022
Cytochrome P450 (CYP) 3A7 is one of the major xenobiotic metabolizing enzymes in human embryonic, fetal, and newborn liver. CYP3A7 expression has also been observed in a subset of the adult population, including pregnant women, as well as in various ...
Md Kabir, Md Kabir, Elias C. Padilha, Pranav Shah, Ruili Huang, Srilatha Sakamuru, Eric Gonzalez, Eric Gonzalez, Lin Ye, Xin Hu, Mark J. Henderson, Menghang Xia, Xin Xu   +12 more
doaj   +1 more source

Micromechanical model of bovine Haversian bone predicts strain amplification through soft interfaces [PDF]

, 2013
Context. Recent observations of brown dwarf spectroscopic variability in the infrared infer the presence of patchy cloud cover. Aims. This paper proposes a mechanism for producing inhomogeneous cloud coverage due to the depletion of cloud particles ...
Nobakhti, Sabah, Katsamenis, Orestis, Andriotis, O., Limbert, Georges, Thurner, Philipp J.   +4 more
core   +4 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Building capacity for collaborative research on opioid and other substance use disorders through the Clinical and Translational Science Award Program

Journal of Clinical and Translational Science, 2020
The opioid crisis in the USA requires immediate action through clinical and translational research. Already built network infrastructure through funding by the National Institute on Drug Abuse (NIDA) and National Center for Advancing Translational ...
Linda B. Cottler, Alan I. Green, Harold Alan Pincus, Scott McIntosh, Jennifer L. Humensky, Kathleen Brady   +5 more
doaj   +1 more source

Unbiased image segmentation assessment toolkit for quantitative differentiation of state-of-the-art algorithms and pipelines

BMC Bioinformatics, 2023
Background Image segmentation pipelines are commonly used in microscopy to identify cellular compartments like nucleus and cytoplasm, but there are few standards for comparing segmentation accuracy across pipelines.
Vishakha Goyal, Nick J. Schaub, Ty C. Voss, Nathan A. Hotaling   +3 more
doaj   +1 more source

Terfenadine resensitizes doxorubicin activity in drug-resistant ovarian cancer cells via an inhibition of CaMKII/CREB1 mediated ABCB1 expression

Frontiers in Oncology, 2022
Ovarian cancer is one of the most lethal gynecological malignancies. Recurrence or acquired chemoresistance is the leading cause of ovarian cancer therapy failure.
Wei Huang, Wei Huang, Shu Yang, Yu-Shan Cheng, Ni Sima, Wei Sun, Min Shen, John C. Braisted, Weiguo Lu, Weiguo Lu, Wei Zheng   +10 more
doaj   +1 more source

Behavioral Recovery and Early Decision Making in Patients with Prolonged Disturbance in Consciousness after Traumatic Brain Injury [PDF]

, 2020
The extent of behavioral recovery that occurs in patients with traumatic disorders of consciousness (DoC) following discharge from the acute care setting has been under-studied and increases the risk of overly pessimistic outcome prediction.
Bagiella, Emilia, Christoforou, Andrea, Giacino, Joseph T., Hammond, Flora M., Long, David, Maurer-Karattup, Petra, Sherer, Mark   +6 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source