Results 41 to 50 of about 1,790,906 (331)

A Comparative Study on New Design Fixation Plate for Parasymphysis of Mandible Fracture with Conventional System

Journal of Pharmacy and Bioallied Sciences
Background: A new non-compression MP has been developed that offers similar benefits to 3D plates and is easier to fix in the PS region (R), as the conceptual design of the plates will allow fx in the PSR while retaining the 3D geometry of the plate. Aim:
Yusuf Ronad, CH V K N S N Moorthy, Pratap Mane, Lishoy W. Rodrigues, Sana Anwar, Dhanu Priya Patel   +5 more
doaj   +1 more source

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance Using structure-based drug design, we have identified a series of potent allosteric protein–protein interaction acetyl-CoA carboxylase inhibitors, exemplified by ND-630, that interact within the acetyl-CoA carboxylase subunit phosphopeptide ...
G. Harriman, J. Greenwood, Sathesh Bhat, Xinyi Huang, Ruiying Wang, D. Paul, L. Tong, A. Saha, William F. Westlin, R. Kapeller, H. James Harwood   +10 more
semanticscholar   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Sensitivity of Nd isotopic composition in seawater to changes in Nd sources and paleoceanographic implications [PDF]

, 2012
It has been argued that past changes in the sources of Nd could hamper the use of the Nd isotopic composition (ϵNd) as a proxy for past changes in the overturning of deep water masses.
Joos, Fortunat, Rempfer, J., Stocker, Thomas, Joos, F., Stocker, T.F., Dutay, Jean-Claude, Dutay, J.-C.   +6 more
core   +2 more sources

Evaluating the Association of Face Covering Mandates on COVID-19 Severity by State

Journal of Primary Care & Community Health, 2022
Objective: During the COVID-19 pandemic in the United States, mitigation measures were implemented on a state-by-state basis. Governors were responsible for establishing interventions appropriate for their states and the timing of implementation.
Mark A. Strand, Omobosinuola Shyllon, Adam Hohman, Rick J. Jansen, Savita Sidhu, Stephen McDonough   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Long-Range Incommensurate Charge Fluctuations in (Y,Nd)Ba2Cu3O6+x [PDF]

Science, 2012
A State of High Tc Superconductivity There are strong indications that high-temperature superconductivity in the cuprates is formed amid competing orders, but only two have been observed unambiguously.
G. Ghiringhelli, M. le Tacon, M. Minola, S. Blanco-Canosa, C. Mazzoli, N. Brookes, G. M. De Luca, A. Frano, D. G. Hawthorn, F. He, T. Loew, M. M. Sala, D. Peets, M. Salluzzo, E. Schierle, R. Sutarto, G. A. Sawatzky, E. Weschke, B. Keimer, L. Braicovich   +19 more
semanticscholar   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Nd-1 de novo assembly statistics.

, 2019
Metrics of assemblies of the Nd-1 nucleome sequence generated by Canu, FALCON, miniasm, and Flye. All described assemblies are the final version after polishing.
Kai Bernd Stadermann (6719021), Daniela Holtgräwe (642655), Katharina Frey (217930), Bernd Weisshaar (34531), Bruno Huettel (270014), Richard Reinhardt (41125), Boas Pucker (3202233)   +6 more
core   +1 more source