The evolutionary history of human spindle genes includes back-and-forth gene flow with Neandertals [PDF]
eLife, 2022 Proteins associated with the spindle apparatus, a cytoskeletal structure that ensures the proper segregation of chromosomes during cell division, experienced an unusual number of amino acid substitutions in modern humans after the split from the ...
Stéphane Peyrégne +3 more
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Optimal linear estimation models predict 1400–2900 years of overlap between Homo sapiens and Neandertals prior to their disappearance from France and northern Spain [PDF]
Scientific Reports, 2022 Recent fossil discoveries suggest that Neandertals and Homo sapiens may have co-existed in Europe for as long as 5 to 6000 years. Yet, evidence for their contemporaneity at any regional scale remains highly elusive. In France and northern Spain, a region
Igor Djakovic +2 more
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Midfacial Morphology and Neandertal–Modern Human Interbreeding [PDF]
Biology, 2022 Ancient DNA from, Neandertal and modern human fossils, and comparative morphological analyses of them, reveal a complex history of interbreeding between these lineages and the introgression of Neandertal genes into modern human genomes.
Steven E. Churchill +2 more
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Proceedings of the National Academy of Sciences of the United States of America, 2016 The last decade has seen a significant growth of our knowledge of the Neandertals, a population of Pleistocene hunter-gatherers who lived in (western) Eurasia between ∼400,000 and 40,000 y ago. Starting from a source population deep in the Middle Pleistocene, the hundreds of thousands of years of relative separation between African and Eurasian groups ...
Wil Roebroeks +2 more
exaly +4 more sources
Variation in cross-sectional indicator of femoral robusticity in Homo sapiens and Neandertals [PDF]
Scientific Reports, 2022 Variations in the cross-sectional properties of long bones are used to reconstruct the activity of human groups and differences in their respective habitual behaviors.
Anna Maria Kubicka +6 more
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Highly selective cannibalism in the Late Pleistocene of Northern Europe reveals Neandertals were targeted prey [PDF]
Scientific ReportsThe Troisième caverne of Goyet has yielded the largest assemblage of Neandertal remains in Northern Europe with clear evidence of anthropogenic modifications.
Quentin Cosnefroy +10 more
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Muscle AMP deaminase activity was lower in Neandertals than in modern humans [PDF]
Nature CommunicationsThe enzyme AMPD1 is expressed in skeletal muscle and is involved in ATP production. All available Neandertal genomes carry a lysine-to-isoleucine substitution at position 287 in AMPD1.
Dominik Macak +6 more
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Rapid change in red cell blood group systems after the main Out of Africa of Homo sapiens [PDF]
Scientific ReportsDespite the advances in paleogenomics, red cell blood group systems in ancient human populations remain scarcely known. Pioneer attempts showed that Neandertal and Denisova, two archaic hominid populations inhabiting Eurasia, expressed blood groups ...
Stéphane Mazières +3 more
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Neandertal introgression partitions the genetic landscape of neuropsychiatric disorders and associated behavioral phenotypes [PDF]
Translational Psychiatry, 2022 Despite advances in identifying the genetic basis of psychiatric and neurological disorders, fundamental questions about their evolutionary origins remain elusive.
Michael Dannemann +12 more
doaj +2 more sources
Evolutionary Origin of Ocular Melanoma: Associations With rs12913832 G Allele Frequency and Latitude. [PDF]
Cancer MedThe rs12913832 derived (G) allele frequency (blue‐eye allele) was a markedly stronger predictor of ocular melanoma incidence than geographic latitude, with approximately 92% of the latitude effect mediated through allele frequency. These findings indicate that pigmentation‐related genetic variation contributes substantially to global differences in ...
Witzenhausen H +4 more
europepmc +2 more sources