Results 71 to 80 of about 256,366 (275)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2008 Article presenting the case study of the "death journey" or near-death experience (NDE) of Don Talayesva, a Hopi Indian, whose experience occurred between 1900 and 1910.
Green, J. Timothy
core +1 more source
, 1986 Article discussing Osirian temple rites of ancient Egypt, which may have involved ceremonial procedures deliberately calculated to induce an experience that was functionally identical to modern near-death ...
Ring, Kenneth
core +3 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
, 1984 This paper discusses Katherine Anne Porter's near-death experience with influenza that influenced her book "Pale Horse, Pale Rider.
Straight, Steve
core +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Interpreting the anomalous : finding meaning in out-of-body and near-death experiences [PDF]
, 2010 Much contemporary research on anomalous experiences has been focused on issues of confirming the authenticity of the phenomena, or to determine the underlying processes by which these phenomena may manifest themselves.
David Wilde +5 more
core +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
, 1982 The author details a near-death experience which has caused him to find a new reality "replete with symbolic meanings that altered his view of life, death, and their intermediate cultural patterns." After his near-death experience (NDE), he faced NDE ...
Gallagher, Patrick
core +1 more source