Results 71 to 80 of about 14,652 (268)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Visual-band Brightnesses of Near-Earth Objects that will be Discovered in the Infrared by NEO Surveyor

The Planetary Science Journal
Near-Earth Object (NEO) Surveyor will detect asteroids and comets using mid-infrared thermal emission, however ground-based followup resources will require knowledge of the expected visible light brightness in order to plan characterization observations.
Joseph R. Masiero, Tyler Linder, Amy Mainzer, Dar W. Dahlen, Yuna G. Kwon   +4 more
doaj   +1 more source

Are Near Earth Objects the Key to Optimization Theory

British Journal of Mathematics & Computer Science, 2013
This note suggests that near earth objects and Central Force Optimization have something in common, that NEO theory may hold the key to solving some vexing problems in deterministic optimization: local trapping and proof of convergence. CFO analogizes Newton's laws to locate the global maxima of a function.
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Internal structure of Near-Earth Objects

Comptes Rendus. Physique, 2005
For the purposes of mitigation, the internal structure of near-Earth objects (NEOs) remains one of the most important but least understood parameters. From a science point of view, the internal structure is equally intriguing. Knowledge of the internal structure can reveal the collisional history, and in the case of comets, may also reveal the ...
Binzel, Richard P., Kofman, Wlodek
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Sensitivity Testing of Stereophotoclinometry for the OSIRIS-REx Mission. II. Effective Observation Geometry for Digital Terrain Modeling

The Planetary Science Journal
The OSIRIS-REx mission used stereophotoclinometry (SPC) to generate digital terrain models (DTMs) of its target asteroid, Bennu. Here we present a suite of preflight tests conducted to identify the observing geometry and number of images needed to create
Eric E. Palmer, John R. Weirich, Robert W. Gaskell, Diane Lambert, Tanner Campbell, Kris Drozd, Olivier S. Barnouin, Michael G. Daly, Kenneth Getzandanner, John N. Kidd Jr., Coralie D. Adam, Dante S. Lauretta   +11 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Placing the Near-Earth Object Impact Probability in Context

The Planetary Science Journal
Near-Earth objects (NEOs) have the potential to cause extensive damage and loss of life on Earth. Advancements in NEO discovery, trajectory prediction, and deflection technology indicate that an impact could be prevented, with sufficient warning time. We
C. R. Nugent, K. P. Andersen, James M. Bauer, C. T. Jensen, L. K. Kristiansen, C. P. Hansen, M. M. Nielsen, C. F. Vestergård   +7 more
doaj   +1 more source