Results 81 to 90 of about 4,318,169 (286)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Size Constraints for the Pre-atmospheric Parent Bodies of Ordinary Chondrites

The Planetary Science Journal
The study of S-complex near-Earth objects (NEOs), the parent bodies of ordinary chondrites, has shown that they are dominated by asteroids with LL chondrite-like compositions. This is surprising because among the three subtypes of ordinary chondrites (H,
Juan A. Sanchez, David C. Cantillo, Adam Battle, Miren Miranda, Benjamin N. L. Sharkey, Tanner S. Campbell, Rogerio Deienno, William F. Bottke, David Nesvorný, Vishnu Reddy   +9 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

On the ballistic capture of asteroids for resource utilisation [PDF]

, 2011
This paper investigates the concept of capturing in the Earth’s neighbourhood Earth-approaching objects such as asteroids and comets. These objects may provide access to potential resources, as well as be potential scientific mission opportunities.
Sanchez Cuartielles, J.P., McInnes, C.R.
core   +2 more sources

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Identifying LL Chondrite Near-Earth Asteroids Using LL Chondrite Reflectance Spectra

The Astrophysical Journal Letters
Most near-Earth objects are thought to originate from the collisional fragments of the main asteroid belt. One question that remains to be resolved is the proportion of near-Earth objects sampling the core area material of the parent body to the outer ...
Pengyue Wang, Edward Cloutis, Ye Su, Man-To Hui   +3 more
doaj   +1 more source

Are Near Earth Objects the Key to Optimization Theory

British Journal of Mathematics & Computer Science, 2013
This note suggests that near earth objects and Central Force Optimization have something in common, that NEO theory may hold the key to solving some vexing problems in deterministic optimization: local trapping and proof of convergence. CFO analogizes Newton's laws to locate the global maxima of a function.
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source