Results 81 to 90 of about 14,652 (268)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Population of Small Near-Earth Objects: Composition, Source Regions, and Rotational Properties

The Planetary Science Journal
The study of small (
Juan A. Sanchez, Vishnu Reddy, Audrey Thirouin, William F. Bottke, Theodore Kareta, Mario De Florio, Benjamin N. L. Sharkey, Adam Battle, David C. Cantillo, Neil Pearson   +9 more
doaj   +1 more source

Development of Radar and Optical Tracking of Near-Earth Asteroids at the University of Tasmania

Remote Sensing
We detail the use of the University of Tasmania’s (UTAS) optical and radio telescopes to conduct observations of near-Earth asteroids from 2021 to 2024.
Oliver James White, Guifré Molera Calvés, Shinji Horiuchi, Phil Edwards, Ed Kruzins, Jon Giorgini, Nick Stacy, Andrew Cole, Chris Phillips, Jamie Stevens, Lance Benner, Edwin Peters   +11 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Near-infrared Spectral Homogeneity of the Didymos System Before and After the DART Impact

The Planetary Science Journal
We spectroscopically characterized the Didymos system, target of the Double Asteroid Redirection Test (DART)/Light Italian Cubesat for Imaging of Asteroids (LICIACube) space mission, close in time to the DART impact event, during six nights between 2022 ...
Simone Ieva, E. Mazzotta Epifani, E. Dotto, V. Petropoulou, J. D. P. Deshapriya, P. H. Hasselmann, G. Poggiali, D. Perna, M. Dall’Ora, A. Lucchetti, M. Pajola, S. L. Ivanovski, A. Rossi, J. R. Brucato, P. Palumbo, V. Della Corte, A. Zinzi, C. A. Thomas, J. de León, T. Kareta, N. Moskovitz, N. L. Chabot, A. S. Rivkin, M. Amoroso, I. Bertini, A. Capannolo, S. Caporali, M. Ceresoli, G. Cremonese, I. Gai, L. Gomez-Casajus, E. Gramigna, G. Impresario, R. Lasagni Manghi, M. Lavagna, M. Lombardo, D. Modenini, S. Pirrotta, P. Tortora, F. Tusberti, M. Zannoni, G. Zanotti   +41 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Potential Interaction of 99942 Apophis with the High Earth Orbit Population during the 2029 Close Approach

The Planetary Science Journal
The asteroid 99942 Apophis will fly by the Earth closer than the geosynchronous (GEO) orbit on 2029 April 13, representing a unique opportunity for investigating a natural event in planetary sciences.
Giulia Schettino, Alessandro Rossi
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optimal detection of near-earth objects [PDF]

, 1997
Improved technology and search strategies could significantly increase debris detection rates and tracking accuracies with modest investment. Improving the focal planes of current telescopes could significantly increase detection rates. For large systems, proportional increases in aperture area and array size are appropriate.
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source