Results 81 to 90 of about 4,153,032 (280)

HIGH-PRECISION FOLLOW-UP OBSERVATIONS OF NEAR-EARTH OBJECTS

Odessa Astronomical Publications, 2018
Main objective of the study is orbit refinement of Near-Earth Objects (NEOs) as part of the global task of asteroid-cometary hazard. We present the latest results of ongoing high-precision astrometric follow-up observations of NEOs using the Mykolaiv ...
N. V. Maigurova, A. V. Pomazan, A. V. Shulga   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Visual-band Brightnesses of Near-Earth Objects that will be Discovered in the Infrared by NEO Surveyor

The Planetary Science Journal
Near-Earth Object (NEO) Surveyor will detect asteroids and comets using mid-infrared thermal emission, however ground-based followup resources will require knowledge of the expected visible light brightness in order to plan characterization observations.
Joseph R. Masiero, Tyler Linder, Amy Mainzer, Dar W. Dahlen, Yuna G. Kwon   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Sensitivity Testing of Stereophotoclinometry for the OSIRIS-REx Mission. II. Effective Observation Geometry for Digital Terrain Modeling

The Planetary Science Journal
The OSIRIS-REx mission used stereophotoclinometry (SPC) to generate digital terrain models (DTMs) of its target asteroid, Bennu. Here we present a suite of preflight tests conducted to identify the observing geometry and number of images needed to create
Eric E. Palmer, John R. Weirich, Robert W. Gaskell, Diane Lambert, Tanner Campbell, Kris Drozd, Olivier S. Barnouin, Michael G. Daly, Kenneth Getzandanner, John N. Kidd Jr., Coralie D. Adam, Dante S. Lauretta   +11 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Placing the Near-Earth Object Impact Probability in Context

The Planetary Science Journal
Near-Earth objects (NEOs) have the potential to cause extensive damage and loss of life on Earth. Advancements in NEO discovery, trajectory prediction, and deflection technology indicate that an impact could be prevented, with sufficient warning time. We
C. R. Nugent, K. P. Andersen, James M. Bauer, C. T. Jensen, L. K. Kristiansen, C. P. Hansen, M. M. Nielsen, C. F. Vestergård   +7 more
doaj   +1 more source

Internal structure of Near-Earth Objects

Comptes Rendus. Physique, 2005
For the purposes of mitigation, the internal structure of near-Earth objects (NEOs) remains one of the most important but least understood parameters. From a science point of view, the internal structure is equally intriguing. Knowledge of the internal structure can reveal the collisional history, and in the case of comets, may also reveal the ...
Binzel, Richard P., Kofman, Wlodek
openaire   +2 more sources