Results 101 to 110 of about 14,583 (268)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Hydration Features on Near-Earth Objects: Integrating New Data with Prior Results

The Planetary Science Journal
Near-Earth objects (NEOs) are excellent laboratories for testing processes that affect airless bodies, as well as informing us about solar system history. Though most NEOs are nominally anhydrous because they formed inside the solar system frost line and
L. E. McGraw, C. A. Thomas, J. P. Emery, A. S. Rivkin   +3 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

DART Impact Ejecta Plume Evolution: Implications for Dimorphos

The Planetary Science Journal
The NASA Double Asteroid Redirection Test (DART) spacecraft impacted the moon Dimorphos of the [65803] Didymos binary system and changed the binary orbit period, demonstrating asteroid deflection by a kinetic impact and indicating that more momentum was ...
Andrew F. Cheng, S. D. Raducan, M. Jutzi, T. L. Farnham, E. Dotto, V. Della Corte, E. Mazzotta Epifani, A. Rossi, I. Gai, J. Deshapriya, P. Hasselmann, I. Bertini, A. Zinzi, S. Ivanovski, J. Brucato, Giovanni Poggiali, A. Lucchetti, M. Pajola, G. Zanotti, M. Amoroso, A. Capannolo, G. Cremonese, M. Dall’Ora, S. Ieva, G. Impresario, M. Lavagna, D. Modenini, P. Palumbo, D. Perna, S. Pirrotta, P. Tortora, M. Zannoni   +31 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Classifying and Characterizing the Evolution of the Minimum Orbit Intersection Distance for Near-Earth Asteroids

The Planetary Science Journal
In this paper, the minimum orbit intersection distances (MOIDs) of near-Earth asteroids (NEAs) over the next 200 yr are computed and analyzed in detail. It is shown that the MOID of an NEA relative to the Earth–Moon barycenter is usually a better metric ...
Shoucun Hu, Yuanyuan Chen, Xinran Li, Xiuhai Wang, Xuefeng Wang   +4 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The Discovery and Characterization of Minimoon 2024 PT5

The Astrophysical Journal Letters
Minimoons are asteroids that become temporarily captured by the Earth–Moon system. We present the discovery of 2024 PT _5 , a minimoon discovered by the Asteroid Terrestrial-impact Last Alert System Sutherland telescope on 2024 August 7.
Bryce T. Bolin, Larry Denneau, Laura-May Abron, Robert Jedicke, Kristin Chiboucas, Carl Ingebretsen, Brian C. Lemaux   +6 more
doaj   +1 more source