Results 111 to 120 of about 4,318,169 (286)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The Planetary Science JournalThe asteroid 99942 Apophis will fly by the Earth closer than the geosynchronous (GEO) orbit on 2029 April 13, representing a unique opportunity for investigating a natural event in planetary sciences.
Giulia Schettino, Alessandro Rossi
doaj +1 more source
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Asteroid deflection and exploitation : possible synergies [PDF]
, 2011 The asteroid and cometary impact hazard has long been recognised as an important issue requiring risk assessment and contingency planning. At the same time asteroids have also been acknowledged as possible sources of raw materials for future large-scale ...
Sanchez Cuartielles, Joan-Pau +1 more
core +2 more sources
Nuclear Mitigation of Hypothetical Asteroid Threats in Smoothed Particle Hydrodynamics
The Planetary Science JournalUnlike many other natural disasters, an impact by an asteroid on Earth may be preventable. One method available to stop an impact is the use of a nuclear explosive device (NED), through either deflection via surface ablation or intentional robust ...
Isaiah B. Santistevan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
The Planetary Science JournalUnderstanding the properties of near-Earth asteroids (NEAs) is key for many aspects of planetary science, particularly planetary defense. Our current knowledge of NEA sizes and regolith properties is heavily dependent on simple thermal models.
Samuel A. Myers +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source