Results 111 to 120 of about 4,153,032 (280)

Surface Heterogeneity, Physical, and Shape Model of Near-Earth Asteroid (52768) 1998 OR2

The Planetary Science Journal
On 2020 April 29, the near-Earth object (52768) 1998 OR2 experienced a close approach to Earth at a distance of 16.4 lunar distances (LD). 1998 OR2 is a potentially hazardous asteroid of absolute magnitude H = 16.04 that can currently come as close to ...
Maxime Devogèle, Anna McGilvray, Eric MacLennan, Courteney Monchinski, Sean E. Marshall, Dylan Hickson, Anne Virkki, Jon D. Giorgini, Lyu Abe, David Augustin, Amadeo Aznar-Macías, Philippe Baudouin, Raoul Behrend, Philippe Bendjoya, Zouhair Benkhaldoun, Josep Bosch, Alberto Cellino, Joseph Chatelain, Marc Deldem, Marin Ferrais, Rui Goncalves, Gerard Houdin, Marek Husárik, Emmanuel Jehin, Teddy Kareta, Myung-Jin Kim, Javier Licandro, Tim Lister, Hissa Medeiros, Petr Pravec, Jean-Pierre Rivet, Gerald Rousseau, Dong-Goo Roh, Brian Skiff, Patrick A. Taylor, Flaviane Venditti, David Vernet, Jean-Michel Vienney, Hong-Suh Yim, Luisa Zambrano-Marin   +39 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A space-based laser system for the deflection and manipulation of near Earth asteroids [PDF]

, 2014
Analysis gained from a series of experiments has demonstrated the effectiveness of laser ablation for the low thrust, contactless deflection and manipulation of Near Earth Asteroids.
Wayman, Alastair, Vasile, Massimiliano, Gibbings, Alison, Hopkins, John-Mark, Watson, Ian A., Eckersley, Steven   +5 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Hydration Features on Near-Earth Objects: Integrating New Data with Prior Results

The Planetary Science Journal
Near-Earth objects (NEOs) are excellent laboratories for testing processes that affect airless bodies, as well as informing us about solar system history. Though most NEOs are nominally anhydrous because they formed inside the solar system frost line and
L. E. McGraw, C. A. Thomas, J. P. Emery, A. S. Rivkin   +3 more
doaj   +1 more source