Results 41 to 50 of about 11,549 (294)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Spectral element method simulation of three-dimensional sedimentary basin under reverse-fault earthquakes

地震科学进展, 2020
Near-fault ground motion can cause serious earthquake disaster in the near-field area，especially when there is sedimentary topography in the area. At present，there are no reports on the ground motion response of sedimentary basins under the action of ...
Zhenning Ba, Jingxuan Zhao, Mengtao Wu, Jianwen Liang, La Ta   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Near-fault and far-fault ground motion effects on cable-supported bridges

, 2017
In this paper a cable-stayed bridge and a suspension bridge with closer main span lengths are considered and the bridge responses obtained from the near-fault and far-fault ground motion cases are compared for both bridge models to underline the relative
Karaca, Hayrettin, Karaca, H., Soyluk, K., Hayrettin Karaca, Kurtulus Soyluk, SOYLUK, KURTULUŞ   +5 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Seismic remote sensing for the earthquake source process and near‐source strong shaking: A case study of the October 16, 1999 Hector Mine earthquake

Geophysical Research Letters, 2000
A new methodology to automatically determine the earthquake source process and near‐source strong ground motions using regional and local distance data was used to study the October 16, 1999 Hector Mine earthquake (MW7.1).
Douglas Dreger, Anastasia Kaverina
doaj   +1 more source

Changes in hot spring temperature and hydrogeology of the Alpine Fault hanging wall, New Zealand, induced by distal South Island earthquakes [PDF]

, 2014
Thermal springs in the Southern Alps, New Zealand, originate through penetration of fluids into a thermal anomaly generated by rapid uplift and exhumation on the Alpine Fault.
Teagle, D.A.H., Cox, S.C., Sutherland, R., Cox, S. C., Denys, P.H., Menzies, C. D., Menzies, C.D., Teagle, D. A. H., Chamberlain, C., Denys, P. H.   +9 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Coseismic displacement estimate of the 2013 M S7.0 Lushan, China earthquake based on the simulation of near-fault displacement field

Earthquake Science, 2016
Usually, GPS observation provides direct evidence to estimate coseismic displacement. However, GPS stations are scattered, sparse and cannot provide a detailed distribution of coseismic displacement.
Hong Zhou
doaj   +1 more source