Results 51 to 60 of about 11,549 (294)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Seismic Response of Skewed Integral Abutment Bridges under Near-Fault Ground Motions, Including Soil–Structure Interaction

Applied Sciences, 2021
Studies on the seismic response of skewed integral abutment bridges have mainly focused on response under far-field non-pulse-type ground motions, yet the large amplitude and long-period velocity pulses in near-fault ground motions might have significant
Qiuhong Zhao, Shuo Dong, Qingwei Wang
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Seismic Collapse Risk Assessment of Braced Frames under Near-Fault Earthquakes

Metals, 2021
Special concentrically braced frames (SCBFs) located in regions close to earthquake faults may be subjected to near-fault ground motions, often characterized by pulses with long periods.
Jeet Kumar Sonwani, Gaofeng Jia, Hussam N. Mahmoud, Zhenqiang Wang   +3 more
doaj   +1 more source

Assessing infrequent large earthquakes using geomorphology and geodesy in the Malawi Rift [PDF]

, 2015
In regions with large, mature fault systems, a characteristic earthquake model may be more appropriate for modelling earthquake occurrence than extrapolating from a short history of small, instrumentally observed earthquakes using the Gutenberg–Richter ...
Biggs, Juliet, Katsuichiro Goda, Hodge, Michael, Goda, Katsuichiro, Aspinall, Willy, Willy Aspinall, Juliet Biggs, Goda, Katsu, Michael Hodge, Aspinall, Willy P   +9 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Optimal Design and Seismic Performance of Base-Isolated Structures with Varying Heights Equipped with Tuned Inerter Dampers Subjected to Far-Fault and Near-Fault Ground Motions

Applied Sciences
This paper investigates the optimal design of base-isolated structures equipped with tuned inerter dampers (TIDs) subjected to various ground motions. The Clough–Penzien model is employed to simulate the power spectrum of three types of ground motions ...
Yingjie Kang, Zewen Zhang, Zeyu Zhang, Xinyu Zhang, Qingkuan Liu   +4 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Experimental Study of Dynamic Responses of Special Tunnel Sections under Near-Fault Ground Motion

, 2023
Data surveys show that near-fault ground motion does great damage to tunnel structures, especially the portal section and fault zone. In this paper, a series of shaking table model tests of near-fault tunnels were conducted and the surrounding-rock fault-
Liping Xian, Lin Li, Deping Guo, Yong Zheng, Yong Tang   +4 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source