Results 41 to 50 of about 5,195 (300)

Study on the shock-absorbing effect of a new staggered story isolated structure under the long-period earthquake motion

Frontiers in Earth Science, 2023
The finite element model of a new staggered story isolated structure is established. Using the time-history analysis method, the dynamic response state of the structure at each time step is calculated by integrating the acceleration time-history data ...
Tong Shu, Qi Li, Taize Wang, Luwei Jiang, Zhongfa Guo, Min Lei, Dewen Liu   +6 more
doaj   +1 more source

Spectral Characterization of Himalayan Near-Fault Ground Motion

Periodica Polytechnica Civil Engineering, 2016
Near-Fault Ground Motion (NFGM) spectral characteristics of three moderate-sized Himalayan earthquakes, viz., the 1986 Dharamsala earthquake (Mw = 5:5), the 1991 Uttarkashi earthquake (Mw = 6:8), and the 1999 Chamoli earthquake (Mw = 6:5) have been studied from the 33 available strong ground motion recordings.
Prabhat Kumar, Ashwani Kumar, Ashok Deota Pandey   +2 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Seismic Response of Base-Isolated Structures with LRB and FPS under near Fault Ground Motions

, 2011
Seismic response of structures in the vicinity of causative earthquake faults can be significantly different than those observed further away from the seismic source.
G. Ghodrati Amiri, Vaez, S.R. Hoseini, S.R. Hoseini Vaez, Amiri, G. Ghodrati, Naderpour, H., M.K. Sharbatdar, H. Naderpour, Sharbatdar, M.K.   +7 more
core   +1 more source

Nonlinear Dynamic Response of a CC-RCC Combined Dam Structure under Oblique Incidence of Near-Fault Ground Motions

Applied Sciences, 2020
The velocity pulse contained in near-fault ground motions have a tremendous impact on dam safety. Previous studies have mainly focused on the response of dams under near-fault seismic records without considering the obliquely incident seismic waves.
Jiawen Zhang, Mengxi Zhang, Mingchao Li, Qiaoling Min, Bowen Shi, Lingguang Song   +5 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Local and global effects of forward directivity

Građevinar, 2013
Previous studies have revealed that near-fault ground motions perpendicular to the fault slip are very destructive for structures. Due to the common use of moment resisting frames and the importance of near-fault strong motions, the local and global ...
Mohsen Gerami, Davood Abdollahzadeh
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source