Results 51 to 60 of about 3,946,171 (298)
Geomatics, Natural Hazards & RiskNear-fault ground motions (NFGMs) differ significantly from far-field ground motions (FFGMs), as NFGMs exhibit pronounced pulse effects and directionality.
Xianqing Cheng +4 more
doaj +1 more source
Evaluation of seismic parameters of steel moment resisting frames based on “FEMA P-695” under near-field rotated ground motion [PDF]
Journal of Structural and Construction Engineering, 2016 Behavior factor (R) is one of the seismic design parameters that considers nonlinear performance of structures during an earthquake. In most of the seismic design codes, behavior factor has been used for considering nonlinear performance of structures in
M. Gerami, A. H. Mashayekhi, N. Siahpolo
doaj
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Impact of Near-Fault Ground Motions on Longitudinal Seismic Response of CHRF Bridges
, 2022 Curved high-pier rigid frame bridges (CHRF bridges) are unavoidably affected by near-fault ground motions (NFGMs), and seismic pounding between adjacent components of CHRF bridge has a significant effect on the seismic performance of CHRF bridges.
Yongrui Zheng +5 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Effect of a Near Fault on the Seismic Response of a Base-Isolated Structure with a Soft Storey
Slovak Journal of Civil Engineering, 2017 This study focuses on the soft-storey behavior of RC structures with lead core rubber bearing (LRB) isolation systems under near and far-fault motions.
Athamnia B., Ounis A., Abdeddaim M.
doaj +1 more source
Effects of Near-Fault Ground Motions on Nuclear Power Plant Containment Structures
, 2022 In this study, it is intended to perform nonlinear time-history analyses of nuclear power plant structures(NPP) under near-fault earthquakes showing directivity pulse and fling-step characteristics.
Yılmaz, Dersu +2 more
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