Results 61 to 70 of about 118,485 (322)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Impact of ground motion characteristics on the seismic fragility of circular tunnels

Underground Space
The seismic performance of tunnel structure can be examined by fragility analysis, which determines the probability that demand will exceed capacity for a given hazard intensity.
Zhong-Kai Huang, Dong-Mei Zhang, Wu-Yu Zhang, Yong-Bo Li   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Scoping prediction of re-radiated ground-borne noise and vibration near high speed rail lines with variable soils [PDF]

, 2014
This paper outlines a vibration prediction tool, ScopeRail, capable of predicting in-door noise and vibration, within structures in close proximity to high speed railway lines.
Woodward, P. K., Verlinden, Olivier, Connolly, D. P., Connolly, D.P., Giannopoulos, Antonis, Woodward, Peter, Kouroussis, Georges, Forde, Mike C, Forde, M.C., Connolly, David, Forde, M. C., Giannopoulos, A, Woodward, P.K., Forde, MC, Kouroussis, G., Verlinden, O, Forde, Mike, Giannopoulos, A.; id_orcid, Giannopoulos, A., Verlinden, O., Woodward, PK, Connolly, DP, Kouroussis, G, Woodward, Peter Keith   +23 more
core   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Coseismic displacement estimate of the 2013 M S7.0 Lushan, China earthquake based on the simulation of near-fault displacement field

Earthquake Science, 2016
Usually, GPS observation provides direct evidence to estimate coseismic displacement. However, GPS stations are scattered, sparse and cannot provide a detailed distribution of coseismic displacement.
Hong Zhou
doaj   +1 more source

Numerical Analysis of Seismic Site Effects in Loess Region of Western China under Strong Earthquake Excitations

Shock and Vibration, 2020
The Loess Plateau is one of the most tectonically and seismically active areas in the world. Observations from past strong earthquakes, particularly the Minxian–Zhangxian and Wenchuan earthquakes, have shown distinctive evidence of seismic site effects ...
Tuo Chen, Zhijian Wu, Yanhu Mu, Ping Wang, Qiyin Zhu   +4 more
doaj   +1 more source

Magnetotail dipolarization and associated current systems observed by Cluster and Double Star [PDF]

, 2008
A dipolarization and its associated current systems are studied using Cluster, Double Star TC1, and ground-based observations. The Cluster spacecraft are located approximately 16 RE downtail near 0030 LT.
Cao, X., A. T. Y. Lui (7591487), X. Cao (2942316), Z. Pu (5722523), C. M. Carr (7592234), Grocott A, Shen C, Kistler, L., Lun, X., Alexeev, I., Lui, A. T. Y., Lui ATY, Mouikis C, Vörös Z, T. L. Zhang (7591511), Fazakerley, A. N., Dunlop, M., Baumjohann W, Shen, C., M. G. G. T. Taylor (7592117), A. Runov (7592228), Runov A, Dunlop, M. W., Klecker B, Zhang, T., Rème, H., Volwerk, M., W. Baumjohann (7592225), Pu, Z., Nakamura, R., Lester, M., Lester M, Z. Vörös (7592231), Runov, A., Grocott, A., Takada T, M. Lester (7589660), A. N. Fazakerley (7591259), C. Shen (1630555), Lun X, B. Klecker (7591355), Alexeev I, Pu Z, Zhang TL, Taylor, M. G. G. T., Zhang, T. L., Nakamura R, Taylor MGGT, Lui, A., J. K. Shi (7591508), Fazakerley, A., Vörös, Z., Shi JK, Klecker, B., M. Volwerk (7591490), Walsh AP, Carr CM, Adrian Grocott (7590026), T. Takada (7591877), Shi, J., Voeroes, Z., Walsh, A., L. M. Kistler (7591505), C. Mouikis (7591502), Takada, T., I. V. Alexeev (7591496), M. W. Dunlop (7591493), Taylor, M., Carr, C. M., Dunlop MW, Baumjohann, W., H. Rème (7591274), Mouikis, C., Kistler L, R. Nakamura (7591343), Volwerk M, Rème H, Carr, C., Cao X, Walsh, A. P., Shi, J. K., A. P. Walsh (7591499), Fazakerley AN, X. Lun (7592222)   +83 more
core   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source