Results 41 to 50 of about 10,126,981 (288)
Analytical comparison between seismic performance of middle-rise bundled tube and 3d moment frame structures [PDF]
پژوهشهای زیرساختهای عمرانی, 2019 In this study, the performance of resistant skeleton of mid-rise moment frames under scaled near-field earthquake records have been evaluated by using both, incremental dynamic and nonlinear dynamic time history analyses.
Vahideh Shirvani Harandi +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Spatial Variability Of Near Field Ground Motions And Its Design Implication Of Long Extended Lifeline Structures Nearby A Fault [PDF]
, 2008 In the near field of a fault rupture, the difference in amplitude, phase, and frequency content of ground motions over extended area, `'spatial variability of ground motions", may be quite large and has an important effect on the response of extended ...
原田, 隆典 +11 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Effects of Near-field and Far-field ground motions on Nonlinear Response of RC Building
, 2023 To perform a design or assessment considering earthquakes, Non-Linear Time History Analysis (NLTHA) is the approach that attempts to fully represent the seismic response of buildings without any of the major simplifying assumptions, such as ignoring ...
Yashwi, Bansal
core +1 more source
Shock and Vibration, 2021 Seismic analysis of tunnels close to or crossing seismogenic faults is a complex problem, which is often neglected at the design stage for the lack of specific codes or guidelines and also because underground structures are considered less vulnerable ...
Xiancheng Mei, Qian Sheng, Zhen Cui
doaj +1 more source