Results 51 to 60 of about 10,126,981 (288)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Longitudinal seismic response of cross-strait shield tunnels under near-fault andfar-field seismic waves

Yantu gongcheng xuebao
Near-fault pulse-like ground motions with long-period velocity pulses may cause severe damage to subsea shield tunnel structures. However, the longitudinal seismic response analysis of such tunnels poses significant computational challenges due to large ...
ZHAO Kai 1, LUO Hao 1, LI Xiaoxiong 2, MU Tengfei 3, 4, KANG Yuxiang 3, 4, ZUO Xi 5, CHEN Guoxing 1
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Vibration Reduction Performance of Structures with Viscous Dampers under Near-Field Earthquakes

Advances in Civil Engineering, 2022
Near-field pulse-type ground motions (NPGMs) are characterized by a high-energy pulse with large peak ground velocities and accelerations and need further studies to confirm whether structures with viscous dampers (VDs) are still applicable and effective
Jianguang Lin
doaj   +1 more source

Seismic Performance Assessment of RC Frame Structures Subjected to Far-Field and Near-Field Ground Motions Considering Strain Rate Effect

, 2018
This paper investigates the influence of strain rate effect on the seismic performance of Reinforced concrete (RC) frame structures subjected to far-field and near-field ground motions.
Rou-Han Li, Hong-Nan Li, Chao Li
core   +1 more source

Determination of a steady velocity field in a rotating frame of reference at the surface of the Earth's core [PDF]

, 1996
We relax the steady-motions theorem by solving for a steady velocity field at the surface of the core in a frame of reference drifting at a linear rate with respect to an observer fixed in the mantle frame of reference.
Whaler, Kathy; id_orcid, Davis, R. G.
core   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Near-Earth substorm features from multiple satellite observations [PDF]

, 2008
We investigate a substorm on 3 October 2004 during which 11 satellites were located in near-Earth magnetotail (XGSM > −10 RE). Double Star 1 (TC-1), Cluster, and LANL-97 satellites were closely aligned in the dawn-dusk direction (
A. T. Y. Lui (7591487), M. G. Henderson (7591460), Grocott A, Shen C, Kistler, L., Henderson MG, Alexeev, I., Lui, A. T. Y., Alexeev IV, Lui ATY, Mouikis C, T. L. Zhang (7591511), Fazakerley, A. N., Dunlop, M., Shen, C., Kistler LM, Dunlop, M. W., Zhang, T., Rème, H., Volwerk, M., Henderson, M., Lester, M., Kistler, L. M., Lester M, Alexeev, I. V., Grocott, A., M. Lester (7589660), A. N. Fazakerley (7591259), C. Shen (1630555), Zhang TL, Zhang, T. L., Lui, A., J. K. Shi (7591508), Fazakerley, A., Shi JK, M. Volwerk (7591490), Walsh AP, Adrian Grocott (7590026), Shi, J., Walsh, A., C. Mouikis (7591502), L. M. Kistler (7591505), M. W. Dunlop (7591493), I. V. Alexeev (7591496), Dunlop MW, H. Rème (7591274), Mouikis, C., Henderson, M. G., Volwerk M, Rème H, Walsh, A. P., Shi, J. K., A. P. Walsh (7591499), Fazakerley AN   +53 more
core   +1 more source