Results 121 to 130 of about 2,559,890 (300)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
THE COMMUTATIVITY OF PRIME NEAR RINGS
International Journal of Research -GRANTHAALAYAH, 2018 Let N be a near-ring, and σ be an automorphisms of N. An additive mapping d from a near-ring N into itself is called a reverse σ-derivation on N if d (xy) = d(y) x + σ(y) d(x), holds for all x, y∈ N. In this paper, we shall investigate the commutativity of N by a reverse σ-derivation d satisfied some properties, when N is a prime ring.
openaire +3 more sources
, 2010 A near-ring N is called an IFP near-ring provided that for all a, b, n is an element of N, ab = 0 implies anb = 0. In this study, the IFP condition in a near-ring is extended to the ideals in near-rings.
Atagun, Akin Osman
core
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
A Ring Associated with a Near-Ring
Journal of Algebra, 1996 Let \(N\) be a right abelian near-ring with identity. The set of all right multiplication maps on \(N\) generates a ring \(R\) which is a subring of \(\text{End}(N)\). The main results are the following ones: 1. If \(N\) is a finite near-field with center \(K\) and \(\dim_KN=n\), then \(R\) is isomorphic to \(M_n(K)^K\). 2.
openaire +2 more sources
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
, 1967 This paper is an attempt primarily to clarify and prove some of the statements left unproved by Gerald Berman and Robert J . Silverman in their article Near Rings which appeared in the January, 1959 issue of The American Mathematical Monthly, Vol.
Alchediak, Michael
core
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Weakly and strongly regular near-rings
, 2005 In this paper, we prove some basic properties of left weakly regular near-rings. We give an affirmative answer to the question whether a left weakly regular near-ring with left unity and satisfying the IFP is also right weakly regular.
N. J. Groenewald +3 more
core +1 more source