Results 141 to 150 of about 2,559,890 (300)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Near rings, fuzzy ideals, and graph theory

, 2013
Near Rings, Fuzzy Ideals, and Graph Theory explores the relationship between near rings and fuzzy sets and between near rings and graph theory. It covers topics from recent literature along with several characterizations.
Satyanarayana, Bhavanari
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Some algebraic identities in 3-prime near-rings

Advances in Pure and Applied Mathematics
Adel En-guady, Abdelkarim Boua, Abderrahmane Raji   +2 more
doaj   +1 more source

Antichiral hinge states in a higher-order photonic nodal ring semimetal. [PDF]

Nat Commun
Peng Y, Mondal D, Yang Y, Wu W, Zhao B, Wei S, Liu Z, Qi W, Dai X, Cheng M, Li W, Zhang X, Li FF, Banerjee R, Wei M, Tian J, Zhou P, Mandal S, Zhang B, Liu GG.   +19 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

On derivations of prime near-rings.

, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Bell, H. E., Boua, A., Oukhtite, L.
openaire   +2 more sources

Topological polaritons in natural uniaxial materials. [PDF]

Nat Commun
Ni X, Wang M, Ma Q, Renzi EM, Alù A.
europepmc   +1 more source

Centralizer near-rings on infinite groups

, 1980
Vita.This work is a continuation of recent work done by Maxson and Smith on finite centralizer near-rings. Our attempt to generalize results which are known to hold for finite centralizer near-rings leads us naturally to a condition on stabilizers of ...
Zeller, Mike
core