Results 151 to 160 of about 2,559,890 (300)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

JWST stellar occultation reveals unexpected changes in Chariklo's ring system. [PDF]

Sci Adv
Santos-Sanz P, Gomes-Júnior AR, Morgado BE, Kilic Y, Kalup C, Kiss C, Pereira CL, Holler BJ, Morales N, Ortiz JL, Sicardy B, Rizos JL, Stansberry J, French RG, Hammel HB, Lin ZY, Souami D, Desmars J, Milam SN, Braga-Ribas F, Assafin M, Benedetti-Rossi G, Camargo JIB, Duffard R, Rommel FL, Fernández-Valenzuela E, Pinilla-Alonso N, Vara-Lubiano M.   +27 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Critical Tracheal Compression by a Double Aortic Arch in a Young Infant: A Case Report. [PDF]

Cureus
Molatedi K, Amod M, Kotze J, Swartbooi A.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

On Anti Fuzzy Primary Ideals of an $(m, n)$-Near Ring

Transactions on Fuzzy Sets and Systems
In this paper, we investigate anti-fuzzy primary ideals in the setting of $(m,n)$-near rings. We study their basic properties and present several characterizations that describe their algebraic structure.
Fahime Mohammadi, Bijan Davvaz
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Structural Prerequisites for Pim-1 Kinase Inhibition and the Identification of a Pyrazolyl-Methylene-Indolinone Hit. [PDF]

Drug Des Devel Ther
Al Zoubi R, Hadieh O, Alnabulsi S, Isawi IH, Liu S.   +4 more
europepmc   +1 more source

On certain classes of near-rings

, 1969
Three special classes of near-rings are studied in this dissertation: near-fields, distributively generated near-rings, and near-rings with zero divisors. Chapter I contains introductory material. In Chapter II various necessary and sufficient conditions
Ligh, Steve Chong Hong
core  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source