Results 151 to 160 of about 1,840,084 (313)

The motion of a singular vortex near an escarpment

open access: yes, 2001
McDonald (1998) has studied the motion of an intense, quasi-geostrophic, equivalent barotropic, singular vortex near an infinitely long escarpment. The present work considers the remaining cases of the motion of weak and moderate intensity singular ...
Johnson, ER, Dunn, DC, McDonald, NR
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Normality in group rings

open access: yes, 2008
Let KG be the group ring of a group G over a commutative ring K with unity. The rings KG are described for which xx(sigma)=x(sigma)x for all x=∑(g∈G)alfa(g)g∈KG, where x↦x(sigma)=∑(g∈G)alfa(g)f(g)sigma(g) is an involution of KG; here f:G→U(K) is a ...
Bódi, Viktor, Siciliano, S.
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Near-Rings

open access: yes, 1967
This paper is an attempt primarily to clarify and prove some of the statements left unproved by Gerald Berman and Robert J . Silverman in their article Near Rings which appeared in the January, 1959 issue of The American Mathematical Monthly, Vol.
Alchediak, Michael
core  

Anti-Fuzzy Ideal in (m, n)-Near Rings

open access: yesTransactions on Fuzzy Sets and Systems
In this article, we introduce and discuss the definitions of fuzzy (m, n)-sub near rings, anti-fuzzy (m, n)- sub near rings, fuzzy ideals, and anti-fuzzy ideals in (m, n)-near rings.
Fahimeh Mohammadi, Bijan Davvaz
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Equiprime near-rings

open access: yes, 2008
Prior to 1990, the only well known ideal-hereditary Kurosh-Amitsur radicals in the variety of zero-symmetric near-rings were the Jacobson type radicals Iv(N) , where ∨∈{2,3} and the Brown-McCoy radical.
Mogae, Kabelo
core  

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