Results 61 to 70 of about 807,286 (280)

A hybrid approach to solve the high-frequency Helmholtz equation with source singularity in smooth heterogeneous media

, 2017
We propose a hybrid approach to solve the high-frequency Helmholtz equation with point source terms in smooth heterogeneous media. The method is based on the ray-based finite element method (ray-FEM), whose original version can not handle the singularity
Fang, Jun, Qian, Jianliang, Zepeda-Núñez, Leonardo, Zhao, Hongkai   +3 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Convergence of the two-point function of the stationary TASEP

, 2013
We consider the two-point function of the totally asymmetric simple exclusion process with stationary initial conditions. The two-point function can be expressed as the discrete Laplacian of the variance of the associated height function.
Baik, Jinho, Ferrari, Patrik L., Péché, Sandrine   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Heterophoria, fusional vergence, and near point of convergence in Sudanese hospital-based population

African Vision and Eye Health
Background: Fusional vergence amplitude is the amount of convergence and divergence that can be induced before fusion is lost and fusional vergence amplitude controls heterophoria.
Saif H. Alrasheed, Sulaiman Aldakhil
doaj   +1 more source

Study of chaos in hamiltonian systems via convergent normal forms

, 1996
We use Moser's normal forms to study chaotic motion in two-degree hamiltonian systems near a saddle point. Besides being convergent, they provide a suitable description of the cylindrical topology of the chaotic flow in that vicinity.
Alfredo M.O. de Almeida, Amol'd, Arnol'd, Arnol'd, Baranger, Berry, Birkhoff, Birkhoff, Churchill, de Matos, de Pinho, Fordy, Gustavson, Hénon, Hénon, Moser, Moser, Ozorio de Almeida, Ozorio de Almeida, Press, Ritter, Werner M. Vieira   +21 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fusional Vergence Detected by Prism Bar and Synoptophore in Chinese Childhood Intermittent Exotropia

Journal of Ophthalmology, 2015
Purpose. To measure the changes in fusional vergence in Chinese children with intermittent exotropia (IXT) and the association with the control of IXT. Methods. Ninety-two patients with IXT (8–15 years old) were compared with 86 controls.
Tao Fu, Jing Wang, Moran Levin, Qing Su, Dongguo Li, Junfa Li   +5 more
doaj   +1 more source