Results 81 to 90 of about 93,246 (266)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Commutativity of near-rings with (σ;τ)-derivations

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2013
In this paper we study some conditions under which a near-ring R admitting a (multiplicative) (σ; τ )-derivation d must be a commutative ring with constrained-suitable conditions on d, σ and τ.
Kamal Ahmed A. M., Al-Shaalan Khalid H.
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

On Prime-Gamma-Near-Rings with Generalized Derivations

International Journal of Mathematics and Mathematical Sciences, 2012
Let 𝑁 be a 2-torsion free prime Γ-near-ring with center 𝑍(𝑁). Let (𝑓,𝑑) and (𝑔,ℎ) be two generalized derivations on 𝑁. We prove the following results: (i) if 𝑓([𝑥,𝑦]𝛼)=0 or 𝑓([𝑥,𝑦]𝛼)=±[𝑥,𝑦]𝛼 or 𝑓2(𝑥)∈𝑍(𝑁) for all 𝑥,𝑦∈𝑁, 𝛼∈Γ, then 𝑁 is a commutative Γ ...
Kalyan Kumar Dey, Akhil Chandra Paul, Isamiddin S. Rakhimov   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Simple and Semisimple Near-Rings [PDF]

Proceedings of the American Mathematical Society, 1953
Algebraic systems with addition and multiplication which satisfy all of the skew-field axioms except possibly one of the distributive laws have been studied occasionally. Dickson [1] gave examples which showed that such systems-called Fastkorper by Zassenhauscan actually be nondistributive.
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Hybrid structure of maximal ideals in near rings

Complex & Intelligent Systems
A hybrid structure is an arrangement that makes use of many hierarchical reporting structures and is applied to algebraic structures such as groups and rings.
B. Jebapresitha
doaj   +1 more source