Results 81 to 90 of about 9,315,628 (295)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Process-structure-performance prediction of nanocomposite overwrapped pressure vessels: Manufacturing-driven design

Composites Part C: Open Access
This work presents a manufacturing-driven multiscale methodology for the design and structural assessment of filament-wound carbon fibre reinforced polymer (CFRP) composite overwrapped pressure vessels (COPVs) incorporating nano-modified epoxy matrices ...
Lyazid Bouhala, Sébastien Klein, Samet Ozyigit, Abdelghani Laachachi   +3 more
doaj   +1 more source

NEAT : A Platform- And Protocol-Independent Internet Transport API [PDF]

, 2017
ACKNOWLEDGMENT The authors would like to thank the anonymous reviewers for their useful remarks. This work has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 644334 (NEAT).
Welzl, Michael,, Bozakov, Zdravko, Fairhurst, Gorry,, Weinrank, Felix, Weinrank, Felix,, David Hayes, Bozakov, Zdravko,, Hurtig, Per, Fairhurst, Gorry, Michael Welzl, Per Hurtig, Welzl, Michael, Ros, David, Zdravko Bozakov, Jones, Tom,, Gorry Fairhurst, Khademi, Naeem, Grinnemo, Karl-Johan, Felix Weinrank, Mangiante, Simone,, Karl-Johan Grinnemo, Michael Tuxen, Hayes, David, Tom Jones, Grinnemo, Karl-Johan, Ros, David,, Anna Brunstrom, Brunström, Anna,, Mangiante, Simone, Brunstrom, Anna, Jones, Tom, Tüxen, Michael, Naeem Khademi, David Ros, Hayes, David,, Tüxen, Michael,, Simone Mangiante, Grinnemo, Karl-Johan,, Hurtig, Per,, Khademi, Naeem,   +39 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Delayed delivery of antibiotics by ultrasound-mediated rupture of polylactic acid pockets: In vitro and in vivo studies.

PLoS ONE
Surgical site infections are a devastating complication of instrumented orthopaedic surgery, particularly in the spine. Bacterial biofilms, once formed on the implant surfaces, exhibit antibiotic tolerance and immune escape, which lead to treatment ...
Selin Isguven Billmyer, Priscilla Machado, Ryan E Tomlinson, Lauren J Delaney, Ji-Bin Liu, Alexander H Harris, Eric McLaughlin, Noreen J Hickok, Flemming Forsberg   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Synergistic effects of Graphene Nanoplatelets and Joncryl ADR on the mechanical and thermal properties of PLA/POM nanocomposites

Scientific Reports
Poly (lactic acid) (PLA) is a bio-based polymer derived from renewable resources; however, its intrinsic brittleness and low ductility limit its wider application in engineering materials.
Ramzi Qasem, Mohd Bijarimi Mat Piah, La Ode Muhammad Zuhdi Mulkiyan, Mugahed Amran, Ali Ahmed Ali Salem, Hanan Kamal, Honin Ali Yahya Al-shaee   +6 more
doaj   +1 more source

Analisis Desain Perpustakaan Sekolah Pada Tingkat Budaya Literasi Siswa SMP Muhammadiyah 10 Surabaya

Aksiologiya: Jurnal Pengabdian Kepada Masyarakat, 2018
This study aims to describe the library design on the interest of reading students SMP Muhammadiyah 10 class VII A. This study was conducted with a descriptive quantitative approach.
Asy'ari Asy'ari
doaj   +1 more source

Implementación de NEAT para redes neuronales adaptables aplicadas a ATARI Asteroids

, 2023
The project's source code can be found in this repository: https://github.com/SantiagoMorenoM/Neat-Python-AsteroidsMastersThe NEAT algorithm grants useful tools for creating agents that beat simple games, as the agents created through it can give simple ...
Moreno Mercado, Santiago
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source