Results 81 to 90 of about 9,713,248 (288)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Research on mix design of fully recycled concrete based on the pore characteristics and rheological principles of recycled aggregates

Results in Engineering
To address the issues of significant performance variability and insufficient theoretical support in the mix design of fully recycled aggregate concrete (FRAC) caused by the high porosity and strong water absorption of recycled aggregates, this study ...
Xianjiang Zhang, Jianhua Li, Kun Huang, Haipeng Wu   +3 more
doaj   +1 more source

Implementation of the NEAT Policy Manager [Elektronisk resurs]

, 2019
The NEAT system was developed in 2017 to increase flexibility in the choice of network transport protocol being used. One of the most important components of the NEAT system is the Policy Manager (PM), which determines what protocol is to be utilized by ...
Tobias, Sjöholm,, Andersson, Jan-Olof,, Larsson, Samuel,   +2 more
core  

Introducing Experience Goals into Packaging Design [PDF]

, 2016
Consumer experiences are an increasingly important driving force for commerce, affecting also packaging design. Yet, experience design for packages is rarely studied.
Roto, Virpi, Virpi Roto, Markus Joutsela, Joutsela, Markus   +3 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A NEAT Approach to Mobile Communication

, 2017
<p>The demands for mobile communication is ever increasing. Mobile applications are increasing both in numbers and in heterogeneity of their requirements, and an increasingly diverse set of mobile technologies are employed.
Anna Brunstrom (5291051), Stefan Alfredsson (5291048), Karl-Johan Grinnemo, Audun Fosselie Hansen, Kristian Evensen (5291045), Rozensztrauch, Tomasz,, Kristian Evensen, Evensen, Kristian,, Tomasz Rozensztrauch (5291057), Fosselie Hansen, Audun,, Anna Brunstrom, Brunström, Anna,, Alfredsson, Stefan,, Tomasz Rozensztrauch, Per Hurtig, Karl-Johan Grinnemo (5291054), Stefan Alfredsson, Audun Fosselie Hansen (5291060), Per Hurtig (5291063), Grinnemo, Karl-Johan,, Hurtig, Per,   +20 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Automatic feature selection using FS-NEAT [PDF]

, 2008
This article describes a series of experiments used to analyze the FS-NEAT method on a double pole-balancing domain. The FS-NEAT method is compared with regular NEAT to discern its strengths and weaknesses.
Whiteson, S., Ethembabaoglu, A.
core   +3 more sources

Genetic NEAT-Based Method for Multi-Class Classification [PDF]

peer reviewedAdvances in the field of NeuroEvolution (NE) highlighted the potential of applying genetic and evolutionary mechanisms to Machine Learning (ML) problems while simultaneously alleviating the need for manual neural architecture design.
Alfaham, Abdallah, Van Raemdonck, Stijn, Mercelis, Siegfried   +2 more
core   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source