Results 11 to 20 of about 5,232 (145)

Dose selection for glycopyrrolate/eFlow® phase III clinical studies: results from GOLDEN (Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer) phase II dose-finding studies [PDF]

Respiratory Research, 2017
Background Long-acting muscarinic antagonists (LAMAs) are recommended for the treatment of chronic obstructive pulmonary disease (COPD). Glycopyrrolate/eFlow® is an investigational drug–device combination of the LAMA glycopyrrolate administered by an ...
James F. Donohue, Thomas Goodin, Robert Tosiello, Alistair Wheeler   +3 more
doaj   +9 more sources

Efficacy of Nebulized Glycopyrrolate on Lung Hyperinflation in Patients with COPD [PDF]

Pulmonary Therapy, 2021
Lung hyperinflation in chronic obstructive pulmonary disease (COPD) is associated with activity limitation, impaired cardiac output, and mortality. Several studies have demonstrated that long-acting muscarinic antagonists (LAMAs) delivered by dry powder inhalers can promote lung deflation; however, the potential of nebulized LAMAs on improving ...
Thomas Siler
exaly   +5 more sources

The Effect of Metabolic Syndrome Status on Lung Function and Patient-reported Outcomes in Patients with COPD Receiving Nebulized Glycopyrrolate [PDF]

Chronic Obstructive Pulmonary Diseases (Miami, Fla ), 2020
Concurrent chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MetS) represent an important clinical phenotype with overlapping symptomology. The effect of MetS in COPD patients was assessed following treatment with nebulized glycopyrrolate (GLY; administered via eFlow® Closed System Nebulizer).Posthoc analyses were performed on pooled
Shahin Sanjar, Gary T Ferguson, Ayça Ozol-Godfrey   +2 more
exaly   +5 more sources

Efficacy and safety of nebulized glycopyrrolate for administration using a high efficiency nebulizer in patients with chronic obstructive pulmonary disease [PDF]

British Journal of Clinical Pharmacology, 2015
Aims To establish the dose−response for pharmacodynamics (bronchodilatation), safety and pharmacokinetics for a nebulized formulation of the long acting muscarinic antagonist glycopyrrolate ( EP ‐101) with a high efficiency nebulizer in patients ...
Dave Singh, Peter J. Barnes
exaly   +5 more sources

Health-Related Quality of Life Improvements in Moderate to Very Severe Chronic Obstructive Pulmonary Disease Patients on Nebulized Glycopyrrolate: Evidence from the GOLDEN Studies [PDF]

Chronic Obstructive Pulmonary Diseases (Miami, Fla ), 2018
Background: Symptoms of chronic obstructive pulmonary disease (COPD) may diminish patients' health-related quality of life (HRQoL). We report effects of Longhala™ Magnair™ (glycopyrrolate) Inhalation Solution, a drug/device combination of the long-acting antimuscarinic glycopyrrolate administered using the eFlow® closed system (eFlow CS) nebulizer, on ...
Edward M Kerwin, James F Donohue, Gary T Ferguson   +2 more
exaly   +5 more sources

Anesthetic Management for Cesarean Delivery in a Pregnant Patient With Spinal Muscular Atrophy Type 2: A Case Report. [PDF]

Case Rep Anesthesiol
Background Spinal muscular atrophy (SMA) Type 2 is a rare autosomal recessive neuromuscular disorder that poses considerable anesthetic challenges in pregnancy, mainly because of restrictive lung physiology, progressive muscle weakness, and spinal deformity.
Lopez Saenz JG, Bonilla Acosta C, Carvajal Villalobos J, Acuna Chinchilla S.   +3 more
europepmc   +2 more sources

Early Antibiotic Discontinuation for Children With a Positive Rapid Respiratory Viral Test Hospitalized for Suspected Bacterial Tracheostomy-Associated Infections. [PDF]

Pediatr Pulmonol
ABSTRACT Objective Test the association between early antibiotic discontinuation and outcomes for children with a tracheostomy and positive respiratory viral PCR (RVP) hospitalized with suspected bTRAIN (bacterial TRacheostomy‐Associated INfection; pneumonia/tracheitis).
Russell CJ, Kono N, Rush M, Hahn A, Forster CS, Cogen JD, DeYoung SH, Morrison JM, Thomson J, Mairal SV, Mack WJ, Neely MN, Simon TD, Pediatric Research in Inpatient Settings Network.   +13 more
europepmc   +2 more sources

Effect of background long-acting beta2-agonist therapy on the efficacy and safety of a novel, nebulized glycopyrrolate in subjects with moderate-to-very-severe COPD

International Journal of COPD, 2018
Edward M Kerwin,1 Robert Tosiello,2 Barry Price,2 Shahin Sanjar,2 Thomas Goodin2 1Clinical Research Institute of Southern Oregon, Inc., Medford, OR, USA; 2Sunovion Pharmaceuticals Inc., Marlborough, MA, USA Background: Phase III studies demonstrated ...
Kerwin EM, Tosiello R, Price B, Sanjar S, Goodin T   +4 more
doaj   +1 more source

Efficacy and safety of a novel, nebulized glycopyrrolate for the treatment of COPD: effect of baseline disease severity and age; pooled analysis of GOLDEN 3 and GOLDEN 4

International Journal of COPD, 2018
Jill Ohar,1 Robert Tosiello,2 Thomas Goodin,2 Shahin Sanjar2 1Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA; 2Sunovion Pharmaceuticals Inc., Marlborough, MA, USA Background: The efficacy and safety ...
Ohar J, Tosiello R, Goodin T, Sanjar S
doaj   +1 more source

Anesthetic Management of a Pregnant Patient With a Large Anterior Mediastinal Mass Undergoing Diagnostic Bronchoscopy: A Case Report. [PDF]

Case Rep Anesthesiol
This case report details the successful use of awake fiberoptic intubation in a 28‐year‐old pregnant patient at 21 weeks gestation, who presented for diagnostic mediastinoscopy with biopsy secondary to a large anterior mediastinal mass suspected to be lymphoma.
Ndoni R, Srinivasan A, Dougherty R, Nahrstedt C, Liu J, Ayad S.   +5 more
europepmc   +2 more sources