Results 91 to 100 of about 2,679,407 (284)

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, EarlyView.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

Interfacial instability induced by lateral vapor pressure fluctuation in bounded thin liquid-vapor layers [PDF]

arXiv, 2008
We study an instability of thin liquid-vapor layers bounded by rigid parallel walls from both below and above. In this system, the interfacial instability is induced by lateral vapor pressure fluctuation, which is in turn attributed to the effect of phase change: evaporation occurs at a hotter portion of the interface and condensation at a colder one ...
arxiv  

Investigation of liquid distribution in gas–solid fluidized beds for fluid cokers

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Thermal cracking processes convert larger molecules into smaller, more valuable products, without a catalyst, allowing for transforming residual oils or waste plastics into useful compounds. Fluid coking, a thermal cracking process utilizing a fluidized bed of hot particles, processes approximately 1 million barrels of residual oil daily. This
Yohann Cochet, Cedric Briens, Franco Berruti, Jennifer McMillan   +3 more
wiley   +1 more source

New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity

ChemMedChem, EarlyView.
A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti, Chin Piaw Gwee, Kitti Wing Ki Chan, Giacomo Pepe, Ciro Milite, Pietro Campiglia, Satoru Watanabe, Muhammad Danial Bin Mohd Mazlan, Stefano Sabatini, Serena Massari, Oriana Tabarrini, Gianluca Sbardella, Subhash G. Vasudevan, Giuseppe Manfroni   +13 more
wiley   +1 more source

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

ChemMedChem, EarlyView.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone, Maria Rosaria Miranda, Francesca Di Matteo, Valeria Napolitano, Michela Aliberti, Simona Musella, Veronica Di Sarno, Gianluigi Lauro, Giuseppe Bifulco, Giacomo Pepe, Giovanna Aquino, Mario Felice Tecce, Isabel Maria Gomez‐Monterrey, Pietro Campiglia, Carmine Ostacolo, Alessia Bertamino, Vincenzo Vestuto, Tania Ciaglia   +17 more
wiley   +1 more source

Uso correcto de la vía inhalatoria en el tratamiento del asma bronquial

Revista Cubana de Medicina General Integral, 2001
Se realizó un estudio descriptivo, transversal en 100 pacientes asmáticos adultos atendidos en el Policlínico Docente "Mario Muñoz Monroy", residentes en el reparto Abel Santamaría, con el objetivo de comprobar si conocen la forma adecuada de usar los ...
Annery Luis Martínez, Dayalín del Cristo Martínez   +1 more
doaj  

An Approach to the Statistics of Turbulence [PDF]

arXiv, 2003
A calculational approach in fluid turbulence is presented. Use is made of the attracting nature of the fluid-dynamic dynamical system. An approximate approach is offerred that effectively propagates the statistics in time. Loss of sensitivity to an initial probability density functional and generation of steady-state statistical effects is suggested.
arxiv  

Hypergolic droplet‒film interaction dynamics at high temperatures

Droplet, EarlyView.
The whole reaction process can be distinctly identified as three stages based on the corona size and the temperature temporal evolution. In the coalescence regime, T* maintains quasi‐stationary values during initial contact, corresponding to hydrodynamic coalescence process. Consequently, the first stage is defined as the inertia‐dominant stage. In the
Yuxin Song, Zuohua Huang, Chenglong Tang
wiley   +1 more source

Pharmacokinetics of Ethyl Glucuronide and Ethyl Sulfate and Pharmacodynamic Effects Following Intravenous and Oral Administration of Ethanol to Exercised Horses

Drug Testing and Analysis, EarlyView.
This study describes the pharmacokinetics of ethanol metabolites following intravenous and oral administration to horses. Based on rapid metabolism, ethyl glucuronide is the best candidate for monitoring of illicit administration to performance horses.
Heather K. Knych, Jeff Blea, Mary Scollay, Philip H. Kass, Daniel S. McKemie   +4 more
wiley   +1 more source

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

Drug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman, Marie H. Deventer, Rachael Andrews, Robert Reid, Victoria Marland, Darren Edwards, Christopher R. Pudney, Niamh Nic Daéid, Christophe P. Stove, Caitlyn Norman   +9 more
wiley   +1 more source