Results 91 to 100 of about 573,097 (333)

NEC rings

Filomat, 2018
A ring R is called NEC if for any a, b ? N(R), ab = ba. The class of NEC rings is a proper generalization of the class of CN rings. First, with the aid of NEC rings, some characterizations of CN rings and reduced rings are given. Next we extend many properties of CN rings to NEC rings such as we show that NEC rings are directly finite and ...
Pan, Yong, Li, Decai, Wei, Junchao
openaire   +3 more sources

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

EMBO Molecular Medicine, 2016
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive symptoms of learning and memory deficits. Such cognitive impairments are attributed to brain atrophy resulting from progressive neuronal and synaptic loss; therefore ...
Seung-Hoon Yang, D. Lee, Jisu Shin, Sejin Lee, Seungyeop Baek, Jiyoon L. Kim, Hoyong Jung, J. Hah, Youngsoo Kim   +8 more
semanticscholar   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Perturbative superluminal censorship and the null energy condition [PDF]

, 1999
We argue that ``effective'' superluminal travel, potentially caused by the tipping over of light cones in Einstein gravity, is always associated with violations of the null energy condition (NEC). This is most easily seen by working perturbatively around
Bassett, Bruce, Liberati, Stefano, Visser, Matt   +2 more
core   +3 more sources

A DATA-DRIVEN APPROACH TO IDENTIFY-QUANTIFY-ANALYSE CONSTRUCTION RISK FOR HONG KONG NEC PROJECTS

Journal of Civil Engineering and Management, 2018
Project risks must be managed to deliver construction projects on time and within budget. In recent years, the New Engineering Contract (NEC) provides an alternate contracting method for procuring construction projects. As stipulated in the NEC contract,
M. Siu, Wing-yan Leung, W. Chan
semanticscholar   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

The Development of Trait Anxiety in Nonhuman Primates During the First Year of Life. [PDF]

Dev Sci
ABSTRACT Anxious temperament (AT) is a nonhuman primate phenotype that models childhood behavioral inhibition, a prominent risk factor for anxiety disorders and stress‐related psychopathology. To understand its earliest antecedents, we characterized AT's developmental trajectory over the first year of life.
Puralewski R, Aggarwal N, Oler JA, Roseboom PH, Parkins L, Riedel MK, Boettcher C, Kalin NH.   +7 more
europepmc   +2 more sources

Pirin Transcriptionally Regulates PLA2G4A To Inhibit Ferroptosis in Colorectal Cancer via Lipid Profile Remodeling

Advanced Science, EarlyView.
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi, Yue Qi Ong, Prativa Majee, Esther SM Wong, Amhed Missael Vargas Velazquez, Kerem Fidan, Pierce Kah‐Hoe Chow, Wai Leong Tam, Ker Kan Tan, Iain Beehuat Tan, Vinay Tergaonkar   +10 more
wiley   +1 more source

Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling

Pediatric Research, 2017
BackgroundNecrotizing enterocolitis (NEC) is a devastating neonatal disease characterized by intestinal necrosis. Hypoxia-inducible factor-1α (HIF-1α) has a critical role in cellular oxygen homeostasis. Here, we hypothesized that prolyl hydroxylase (PHD)
Rakhee M. Bowker, Xiaocai Yan, Elizabeth Z Managlia, S. Liu, Catherine Marek, Xiao-Di Tan, Isabelle G. De Plaen   +6 more
semanticscholar   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source