4‐Hydroxytamoxifen induces a noncanonical ferroptosis in lung adenocarcinoma by targeting AKR1B10
4‑OHT directly inhibits AKR1B10 enzymatic activity to induce noncanonical ferroptosis in LUAD. AKR1B10 sustains LUAD survival by stabilising ACC1 and detoxifying reactive carbonyl species (RCSs). Nanatinostat similarly targets AKR1B10 and elicits the same cell death modality.
Hui Yang +8 more
wiley +1 more source
Safety and efficacy of restrictive red blood cell transfusion strategy in extremely low birth weight infants: a before-after comparative study. [PDF]
Xu X, Xu X, Zhao Q.
europepmc +1 more source
PMU‐Based Wide Area Monitoring With Machine Learning to Prevent Blackouts in Bangladesh Power System
A Unified Real‐time Dynamic State Measurements (URTDSM) system with PMU and Phasor Data Concentrator (PDC) deployment plan has been proposed to avoid blackout in the Bangladeshi power system. Machine learning has been used to process data from PMU to identify abnormal events. ABSTRACT The electrical power system must be trustworthy and secure enough to
Imi Bintey Fariha Rahman +5 more
wiley +1 more source
Historical Evolution of Terminology and Current Classification of Neuroendocrine Neoplasms of the Larynx and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms (MiNENs): A Narrative Review. [PDF]
Bradová M, Agaimy A, Ferlito A.
europepmc +1 more source
Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
A Novel Rectal Propranolol Strategy in Neonatal Supraventricular Tachycardia Complicated by Surgical Necrotizing Enterocolitis. [PDF]
Siddharth M +7 more
europepmc +1 more source
LIPE‐AS1 is markedly upregulated and serves as a competitive endogenous RNA that sponges miR‐330‐3p. This sequestration relieves miR‐330‐3p‐mediated repression of MGAT5, leading to elevated MGAT5, which subsequently suppresses cuproptosis‐related proteins FDX1, DLAT, and DLST, thus diminishing cuproptosis sensitivity.
Qiang Shen +18 more
wiley +1 more source
When Transfer Is Impossible: Emergency Management of Perforated Necrotizing Enterocolitis in a Neonate With Uncorrected Dextro-Transposition of the Great Arteries. [PDF]
Eckardt V, Gao D, Marques C.
europepmc +1 more source
Design and imaging performance of BPET–DBT – a dedicated scanner for breast imaging
Abstract Background A dedicated breast PET (BPET) scanner integrated with digital breast tomosynthesis (DBT) enables three‐dimensional functional imaging with quantitative information co‐registered to high‐resolution anatomical images. With the availability of breast cancer specific PET radiotracers, such a scanner has the potential to improve ...
Srilalan Krishnamoorthy +12 more
wiley +1 more source

