Results 91 to 100 of about 4,848 (199)

Changed gluten immunity in celiac disease by Necator americanus provides new insights into autoimmunity

, 2013
We recently completed clinical trials in people with diet-treated celiac disease who were purposefully infected with the ubiquitous human hookworm, Necator americanus.
Gaze, Soraya T., Croese, John, Loukas, Alex   +2 more
core   +1 more source

A proof of concept study establishing Necator americanus in Chrohn's patients and reservoir donors

, 2006
[Extract] The emergence of autoimmunity, including Crohn’s disease (CD) where the immune relationship with commensal bacteria is corrupted, has been linked to hygiene.1 2 A gradual decline in endoparasites is but one argument that might explain this ...
O'Neil, J., Pritchard, D., Melrose, W., Speare, R., Croese, J., Cooke, S., Masson, J.   +6 more
core   +1 more source

Not your typical hookworm infection—a case report from the Peruvian Amazon and review of the literature

Therapeutic Advances in Infectious Disease
Human hookworm infection is caused by the nematodes Necator americanus , Ancylostoma duodenale , and Ancylostoma ceylanicum . Iron deficiency anemia is the hallmark of chronic, moderate-to-heavy-intensity infections, promoting a vicious poverty cycle ...
Edgar A. Ramirez-García, Ricci A. Chafloque-Vasquez, Angel A. Moreno-Soto, Jhosephi J. Vásquez-Ascate, Marco F. Paredes-Obando, Nelson Iván Agudelo Higuita, Andrés F. Henao-Martínez, Carlos Franco-Paredes, Luis A. Marcos, Juan C. Celis Salinas, Martín Casapía-Morales   +10 more
doaj   +1 more source

Modelling the ecological niche of hookworm in Brazil based on climate

Geospatial Health, 2012
The distribution of hookworm in schistosomiasis-endemic areas in Brazil was mapped based on climate suitability. Known biological requirements of hookworm were fitted to data in a monthly long-term normal climate grid (18 x 18 km) using geographical ...
Ntombi B. Mudenda, John B. Malone, Michael T. Kearney, Paula D. Mischler, Prixia del Mar Nieto, Jennifer C. McCarroll, Penelope Vounatsou   +6 more
doaj   +1 more source

The production of Necator americanus larvae for use in experimental human infection. [PDF]

Parasit Vectors, 2022
Chapman PR, Llewellyn S, Jennings H, Becker L, Giacomin P, McDougall R, Robson J, Loukas A, McCarthy J.   +8 more
europepmc   +1 more source

Necator americanus: characterisation of secreted proteinases and vaccine development [PDF]

, 2000
The proteinases present in Necator americanus larval excretory/secertory (ES) products were characterised using FITC labelled casein and shown to have a pH optimum of pH 6.5 with lesser peak of activity at pH 8.
Brown, AP
core  

Improved insights into the transcriptomes of the human hookworm Necator americanus: fundamental and biotechnological implications

, 2009
Hookworms of humans are blood-feeding parasitic nematodes of major socio-economic significance in a wide range of countries. They cause a neglected tropical disease (NTD) called "hookworm disease" ( = necatoriasis and/or ancylostomiasis).
Hu, M., Gasser, R.B., Rabelo, Elida M., Loukas, A., Gasser, Robin B., Rabelo, E.M., Cooper, L., Cooper, Leanne, Ranganathan, S., Hall, Ross S., Ranganathan, Shoba, Hu, Min, Hall, R.S., Loukas, Alex   +13 more
core   +1 more source

Proteolytic degradation of hemoglobin in the intestine of the human hookworm necator Americanus

, 2009
Blood-feeding parasites use mechanistically distinct proteases to digest hemoglobin (Hb), often as multienzyme cooperative cascades. We investigated the roles played by 3 distinct proteases from adults of the human hookworm Necator americanus.
Lowthe, Jonathan, Pearson, Mark, Gorman, Jeffrey, Stenzel, Deborah, Loukas, Alex, Hotez, Peter, Ranjit, Najju, Zhan, Bin, Hamilton, Brett, Lowther, Jonathan   +9 more
core   +1 more source

Cuticle preparations from Necator americanus and their immunogenicity in the infected host.

, 1988
Cuticle samples have been prepared from the human parasitic nematode Necator americanus using detergent solubilisation with sodium dodecyl sulphate and subsequent reduction of disulphide bonds using 2-beta-mercaptoethanol.
Rogan, Michael Thomas, Pritchard, David Idris, McKean, Paul G.   +2 more
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The novel interactions of Necator americanus with the innate immune system and The development of a 3D immunocompetent model of human skin [PDF]

, 2018
Background: Necatoriasis is a neglected tropical disease caused by the insidious parasite Necator americanus. This hookworm infects and reinfects approximately 500 million individuals worldwide, with a further 5.1 billion at high risk for acquiring the ...
Hassan, Asha
core