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Advances in vaccine development through the controlled human infection models for hookworm and schistosomiasis. [PDF]
PLoS Negl Trop DisHoogerwerf MA +4 more
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Helminth infection is linked to an impaired neutralisation response to SARS-CoV-2 post vaccination
McCormack MJ +11 more
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Serological reactions to infection with Necator americanus
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1969Abstract Experimental human infection with larvae of Necator americanus gave rise to immediate antibody responses, demonstrable by fluorescent antibody, complement fixation and Prausnitz-Kustner reactions, which recurred after subsequent challenges. Haemagglutinating antibodies were detected 2 years after, first infection.
P A, Ball, A, Bartlett
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Endoscopic Discovery and Capture of Necator americanus in the Stomach
Endoscopy, 1983We report a case of the endoscopic discovery and removal of a specimen of Necator americanus hooked into the gastric mucosa of a black woman from Zaire. We extracted the parasite by means of biopsy forceps. Signs of previous bites were seen in the antrum. This exceptional localization might be due to a jejuno-duodeno-gastric reflux.
A, Dumont, V, Seferian, P, Barbier
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Antibody responses in self-infections with Necator americanus
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1978Antibody responses were measured in a volunteer infected four times with Necator americanus over a 27-month period. The main source of antigen was culture fluid in which living adult N. americanus had been maintained for several days. Antibodies to worm acetylcholinesterase and IgE antibodies were detected only with this material, but antibodies were ...
B M, Ogilvie +5 more
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Necator americanus Infection in Primates
The Journal of Parasitology, 1971Laboratory-bred and feral chimpanzees (Pan troglodytes) and young, laboratory-bred, patas monkeys (Erythrocebus patas) exposed to infective larvae of Necator americanus cultured from human feces developed patent infections in 42 to 54 days; adult, feral patas monkeys were refractory to infec- tion.
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Necator americanus: Behaviour in hamsters
Experimental Parasitology, 1972Abstract The human hookworm, Necator americanus originally isolated from a patient was serially passed in golden hamsters over a period of 4 years. The parent and four succeeding populations were passed in these animals under cortisone. Adaptation of these parasites to the hamster occurred from the sixth serial passage and thereafter following the ...
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Radioactive tagging of hookworm larvae (Necator americanus) with P32
Experimental Parasitology, 1958Abstract Larvae of Necator americanus were successfully tagged with P32 by cultivation of the larvae through the free-living stages in the presence of the isotope. The degree of absorption of P32 by the larvae was influenced by the strength of P32 in the cultures, the addition of bacteria previously activated, and by the nature of the medium for ...
G A, DISSANAIKE +2 more
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Identification of hookworm (Necator americanus) antigens and their translation in vitro
Molecular and Biochemical Parasitology, 1986During in vitro culture adult (day 35) Necator americanus synthesise a wide range of protein species many of which are excreted or secreted into the culture medium. Both post infection (day 117) hamster sera and sera from infected humans precipitate antigens of 15, 30, 33, 44, 46 and 69 kDa although individual human sera exhibit some variability in ...
A, Carr, D I, Pritchard
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