Results 51 to 60 of about 2,797,259 (404)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

DMRG-CASPT2 study of the longitudinal static second hyperpolarizability of all-trans polyenes [PDF]

open access: yes, 2016
We have implemented internally contracted complete active space second order perturbation theory (CASPT2) with the density matrix renormalization group (DMRG) as active space solver [Y. Kurashige and T. Yanai, J. Chem. Phys.
Van Neck, Dimitri   +2 more
core   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Immature congenital teratoma of the neck: a very rare entity

open access: yesPAMJ Clinical Medicine, 2019
Congenital teratoma is a very rare tumor, affecting the neck in 3% of all cases.The diagnosis should be performed in antenatal by ultrasonography or magnetic resonance imaging (MRI). The risk of neonatal respiratory distress is very important. We present
Abderrahim Siati   +3 more
doaj   +1 more source

Test–retest Reliability and Concurrent Validity of a Headphone and Necklace Posture Correction System Developed for Office Workers

open access: yesPhysical Therapy Korea, 2023
Background: Office workers experience neck or back pain due to poor posture, such as flexed head and forward head posture, during long-term sedentary work. Posture correction is used to reduce pain caused by poor posture and ensures proper alignment of
Gyu-hyun Han   +4 more
doaj   +1 more source

Creation of wormholes by quantum tunnelling in modified gravity theories

open access: yes, 2014
We study the process of quantum tunnelling in scalar-tensor theories in which the scalar field is non-minimally coupled to gravity. In these theories gravitational instantons can deviate substantially from sphericity and can in fact develop a neck - a ...
Battarra, Lorenzo   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Contents Vol. 39 No. 2 July-December 2024

open access: yesPhilippine Journal of Otolaryngology Head and Neck Surgery
EDITORIAL 4 Original Research: Descriptive or Analytical, Either-Or or Both-And? Lapeña JFF SPECIAL ANNOUNCEMENT 6 Sydney Declaration on Predatory or Pseudo Journals and Publishers APAME WPRIM IMSEAR ORIGINAL ARTICLES   7 ...
Philip J Otolaryngol Head Neck Surg
doaj   +1 more source

υ-representability of one-body density matrices [PDF]

open access: yes, 2001
We consider low-dimensional model systems with a fixed two-body interaction and a variable (nonlocal) one-body potential. It is shown explicitly that an extended domain of allowed (N-representable) one-body density matrices cannot be generated in this ...
Dewulf, Yves   +4 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

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