Results 81 to 90 of about 1,754,745 (360)

Neck lift [PDF]

Aesthetic Surgery Journal, 2003
The treatment of the aging neck is still a challenge to the plastic surgeon.The results of anatomic studies of the platysma muscle and its role in the treatment of the aging neck are presented.Dissection of 50 cadavers revealed differences in the distribution of the medial fibers of the platysma muscle in the suprahyoid region that could significantly ...
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Genetics of hereditary head and neck paragangliomas

, 2014
Item does not contain fulltextBACKGROUND: The purpose of this study was to give an overview on hereditary syndromes associated with head and neck paragangliomas (HNPGs).
Maier, W., Nederveen, Francien H. van, Ferlito, Alfio, Takes, Robert P., Hensen, E.F., Pellitteri, P.K., Hensen, Erik F., Suárez, Carlos, Maier, Wolfgang, Rinaldo, Alessandra, Kunst, H.P., Rodrigo Tapia, Juan Pablo, Nederveen, F.H. van, Boedeker, Carsten Christof, Rodrigo, Juan P., Takes, R.P., Ferlito, A., Suárez Nieto, Carlos, Pellitteri, Phillip K., van Nederveen, F.H., Kunst, H.P.M., Neumann, H.P., Neumann, Hartmut P. H., Neumann, H.P.H., Suarez, C., Kunst, Henricus P., Boedeker, C.C., Rodrigo, J.P., Rinaldo, A.   +28 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Retropharyngeal Lymph Node Metastases in Head and Neck Malignancies

, 2010
Item does not contain fulltextRetropharyngeal lymph node (RPLN) metastasis of primary head and neck cancer often receives less consideration than lymph node metastasis in the neck. With improvements in imaging techniques and reports of surgical pathology,
Shaha, Ashok R., Medina, JE, Robbins, KT, Woolgar, J.A., Bree, R. de, H. Hakan Coskun, Remco de Bree, Ferlito, Alfio, Robbins, K. Thomas, Takes, Robert P., Alessandra Rinaldo, Rinaldo, Alessandra, Juan P. Rodrigo, Rinaldo, A, Strojan, Primoz, Rodrigo, Juan P., Suarez, Carlos, Takes, R.P., Shaha, AR, Ferlito, A., Robbins, K.T., Alfio Ferlito, Woolgar, Julia A., Julia A. Woolgar, de Bree, Remco, Jesus E. Medina, Robert P. Takes, Silver, Carl E., Coskun, H.H., Strojan, P., Carlos Suárez, K. Thomas Robbins, de Bree, R., Medina, J.E., Ashok R. Shaha, Suarez, C., Silver, C.E., Shaha, A.R., Ferlito, A, Primož Strojan, Rodrigo, J.P., Medina, Jesus E., Rinaldo, A., Carl E. Silver   +43 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Disputatio inauguralis continens quaestiones miscellaneas ex iure civili, canonico, feudali, et publico depromptas

quam ... pro summo in utroque iure gradu, privilegiis ac honoribus doctoralibus impetrandis publicè, horis locoque consuetis, discutiendam proponit Nicolaus Neck Horna-Batavus, ad diem Octobr. anno MDCXXXII.Druckjahr nach der Datierung im TitelEnthält 32
Neck, Nicolaus
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source