Results 51 to 60 of about 98,602 (295)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Ipsilateral Acetabular and Femoral Neck and Shaft Fractures

Case Reports in Orthopedics, 2015
Floating hip injuries and ipsilateral femoral neck and shaft fractures are rare. Additionally, the simultaneous occurrence of these injuries is extremely rare, and only one case report of the simultaneous occurrence of these injuries has been published ...
Hideto Irifune, Suguru Hirayama, Nobuyuki Takahashi, Eichi Narimatsu   +3 more
doaj   +1 more source

Miraculous escape in a case of penetrating neck injury by arrow

Indian Journal of Vascular and Endovascular Surgery, 2021
Penetrating neck injuries due to arrowheads have become extremely rare in most of the nations. Although the basic principles of management remain the same as that of other penetrating injuries, certain extra precautions need to be taken while managing ...
Raja Lahiri, Subhendu Sekhar Mahapatra
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Does inter-vertebral range of motion increase after spinal manipulation? A prospective cohort study. [PDF]

, 2014
Background: Spinal manipulation for nonspecific neck pain is thought to work in part by improving inter-vertebral range of motion (IV-RoM), but it is difficult to measure this or determine whether it is related to clinical outcomes.
Alan C Breen, Branney, Jonny, Branney, Jonathan, Jonathan Branney, Breen, Alan C., Breen, Alan   +5 more
core   +1 more source

Facing Facts: Facial Injuries from Stand-up Electric Scooters [PDF]

, 2020
Background Stand-up electric scooters (SES) are a popular public transportation method. Numerous safety concerns have arisen since their recent introduction.
Alwani, Mohamedkazim, Bandali, Elhaam, Sim, Michael W., Lancaster, Benjamin, Sandelski, Morgan, Shipchandler, Taha, Ting, Jonathan, Jones, Alexander J.   +7 more
core   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Incidence and prevalence of complaints of the neck and upper extremity in general practice [PDF]

, 2005
OBJECTIVE: To study the incidence and prevalence of neck and upper extremity musculoskeletal complaints in Dutch general practice. METHODS: Data were obtained from the second Dutch national survey of general practice.
Bot, Sandra D.M., Bouter, L. M., Schellevis, F. G., Waal, J.M. van der, Schellevis, F.G., Dekker, J., Van Der Waal, J. M., Bouter, L.M.; id_orcid, Terwee, C. E., Terwee, C.B., Windt, D.A.W.M. van der, Windt - Mens, D.A.W.M. van der, Bouter, L.M., Bot, S.D.M., van der Windt-Mens, D.A.W.M., van der Waal, J.M., Van Der Windt, D. A.W.M.   +16 more
core   +2 more sources

Non-accidental head and neck injuries in children and adolescents. [PDF]

J Forensic Odontostomatol, 2022
Child abuse or maltreatment has been a global problem and research shows that more than half of the cases present with head and neck injuries. This study aimed to propose an online referencing platform for dental professionals to know more about signs of
Anees W, Franco A, Manica S.
europepmc   +3 more sources

Paramagnetic Rim Lesions Are Associated With Trans‐Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan, Mustafa Subhi, Elaina Luskin, Bryan Quah, Sreekanth Madhusoodhanan Nair, Arzu C. Has Silemek, Gabriela Zabala, Yujie Cui, Laura Locke, Paula Barreras, Marwa Kaisey, Vinicius Calsavara, Daniel S. Reich, Nancy L. Sicotte, Pascal Sati, Omar Al‐Louzi   +17 more
wiley   +1 more source