Results 51 to 60 of about 271,141 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Myofascial Trigger Points in Children With Tension-Type Headache: A New Diagnostic and Therapeutic Option [PDF]

, 2009
The goal of this pilot study was to evaluate the effect of a trigger point–specific physiotherapy on headache frequency, intensity, and duration in children with episodic or chronic tension-type headache. Patients were recruited from the special headache
Blaschek, Astrid, Heinen, Florian, Henschel, Volkmar, Lee, Seung-Hee, Mansmann, Ulrich, Müller-Felber, Wolfgang, Reilich, Peter, Schäfer, Jan, Straube, Andreas, Stülpnagel, Celina von   +9 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Investigations of upper crossed syndrome’s characteristics in dental students

Journal of Associated Medical Sciences, 2017
Background: From biomechanical dimension, working position of dentist is a prolonged trunk forward bending and forward shoulder posture during clinical practice.
Thanaporn Srijessadarak, Daraporn Sae-Lee, Aatit Paungmali, lugkana mato, sawitri wanpen, Sauwanan Bumrerraj, Yodchai Boonprakob   +6 more
doaj  

Alterations in 18F-FDG accumulation into neck-related muscles after neck dissection for patients with oral cancers [PDF]

, 2016
Background: 18 F-fluoro-2-deoxy-D-glucose ( 18 F-FDG) accumulations are commonly seen in the neck-related muscles of the surgical and non-surgical sides after surgery with neck dissection (ND) for oral cancers, which leads to radiologists having ...
Habu, Manabu, Kito, Shinji, Kodama, Masaaki, Koga, Hirofumi, Kokuryo, Shinya, Matsumoto-Takeda, Shinobu, Matsuo, Kou, Miyamoto, Ikuya, Morimoto, Yasuhiro, Nishimura, Shun, Nishino, Takanobu, Oda, Masafumi, Sasaguri, Masaaki, Tanaka, Tatsurou, Tominaga, Kazuhiro, Uehara, Masataka, Yoshiga, Daigo, Yoshioka, Izumi   +17 more
core   +2 more sources

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Differential postural effects of plantar-flexor muscles fatigue under normal, altered and improved vestibular and neck somatosensory conditions

, 2008
The aim of the present study was to assess the effects of plantar-flexor muscles fatigue on postural control during quiet standing under normal, altered and improved vestibular and neck somatosensory conditions.
A Kavounoudias, A Nardone, A Straube, A Tagaki, BS Davidson, BS Hassan, F Hlavacka, F Hlavacka, FB Horak, G Borg, GG Simoneau, GG Simoneau, GM Ryan, HG MacDougall, J Treleaven, J Treleaven, J Vaillant, JG Buckley, JT Inglis, KS Oie, LM Nashner, LM Nashner, M Cenciarini, M Karlberg, M Lacour, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, N Vuillerme, Nicolas Pinsault, Nicolas Vuillerme, O Dzurková, PA Fransson, PJ McNair, R Fitzpatrick, RA Schmidt, RJ Peterka, RJ Peterka, RJ Peterka, RT Jackson, SW Trappe, T Brandt, T Ledin, TB Birmingham, TH Brandt, TW Kaminski, V Anand, V Anand, YP Ivanenko   +56 more
core   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

The effects of childbirth on the pelvic-floor [PDF]

, 2000
Basically, vaginal delivery is associated with the risk of pelvic floor damage. The pelvic floor sequelae of childbirth includes anal incontinence, urinary incontinence and pelvic organ prolapse.
Allen RE, Anthony S, Frudinger A, Frudinger A, Gilpin S, Jackson S, Johanson RB, King JK, Labrecque M, Mac Arthur C, Mant J, Pigne A, Rasmussen KL, Rockner G, Sleep J, Smith AR, Snooks SJ, Sultan AH, Sultan AH, van Geelen J, Vessey MP, Viktrup L, Viktrup L, Wilson PD, Zetterstrom JP   +24 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source