Results 171 to 180 of about 9,104 (307)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Analysis of Strain Hardening Processes of AISI 316 LN Austenitic Stainless Steel. [PDF]
Materials (Basel)Kvačkaj T +4 more
europepmc +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Hydrogen Embrittlement and Failure Mechanisms in Fe-18Mn-8Al-1C-5Ni Steel with Dual B2/κ-Carbide Precipitates. [PDF]
Materials (Basel)Li J, Guo Z, Qian Y, Guo X, Ding H.
europepmc +1 more source
Advanced Science, EarlyView.The pholidota‐inspired electronic skin is successfully constructed, originally realized four‐state reversible switching of terahertz‐wave reflection, absorption, transmission, and secondary reflection. In response to external demands, it issues deformation instructions, verifies the deformation state after the equipment executes the action, and thus ...
Shangjing Li +4 more
wiley +1 more source
Formability Limits in Square Tubes and L-Section Profiles. [PDF]
Materials (Basel)Almeida IM, Magrinho JPG, Silva MB.
europepmc +1 more source
Advanced Science, EarlyView.Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green +15 more
wiley +1 more source
Unidirectional Ligament Orientation Enables Enhanced Out-of-Plane Mechanical Properties in Anisotropic Nanoporous Gold. [PDF]
Nanomaterials (Basel)Zhang Y, Liu X, Hu Y, Ding S, Tang F.
europepmc +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Mechanistic Investigation of Microdroplet Formation in High-Viscosity Shear-Thinning Hydrogel Bioinks. [PDF]
GelsGao Q +6 more
europepmc +1 more source