Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy
Advanced Healthcare Materials, EarlyView.Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima +15 more
wiley +1 more source
Scaphotrapeziotrapezoid Fusion for Chemotherapy-induced Capitate Avascular Necrosis. [PDF]
Plast Reconstr Surg Glob OpenFarzan JJ, Barron SL, Wong A.
europepmc +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, EarlyView.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery
Advanced Healthcare Materials, EarlyView.A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu +7 more
wiley +1 more source
Percentage signal recovery plus relative cerebral blood volume: a practical dual-parameter strategy for differentiating post-stereotactic radiosurgery tumour progression from radiation necrosis in brain metastases. [PDF]
Insights ImagingSawlani V +10 more
europepmc +1 more source
Microengineered Gradient Hydrogels for Mechanobiology
Advanced Healthcare Materials, EarlyView.Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong +4 more
wiley +1 more source
A nomogram for predicting free flap necrosis in soft tissue reconstruction of lower limbs: a retrospective cohort study. [PDF]
Front Med (Lausanne)Cheng C, Huang X, Liang H, Jiang Z.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Metabolic labeling of nascent proteins in 3D microtissue spheroids provides a powerful analytical approach for large‐scale tissue engineering. Incorporation of non‐canonical amino acids with fluorescent tagging enables spatiotemporal investigation of extracellular matrix deposition and its evolution during multicellular tissue development and fusion ...
Theresa Koenig +3 more
wiley +1 more source
Reply to the Letter to the Editor: Diagnostic performance of the clear cell likelihood score integrated with cystic degeneration or necrosis on MR imaging for identifying clear cell renal cell carcinoma in cT1 solid renal masses. [PDF]
Insights ImagingNing X, Wang H.
europepmc +1 more source
Advanced Healthcare Materials, EarlyView.Microfluidic coaxial extrusion generates size‐controlled 3D lymphatic tubes from primary human dermal lymphatic endothelial cells in a defined four‐component matrix. These engineered vessels self‐organize into stable lymphatic endothelium, maintain selective macromolecular permeability for 30 days, and enable direct comparison with blood endothelial ...
Elsa Mazari‐Arrighi +8 more
wiley +1 more source