Results 11 to 20 of about 1,608,164 (308)

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

International Journal of Molecular Sciences, 2021
Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two
Dan-in Jang, A-Hyeon Lee, Hye-Yoon Shin, Hyo-Ryeong Song, Jong-Hwi Park, T. Kang, Sang-Ryong Lee, Seung-Hoon Yang   +7 more
semanticscholar   +1 more source

PD-L1-Mediated Gasdermin C Expression Switches Apoptosis to Pyroptosis in Cancer Cells and Facilitates Tumor Necrosis

Nature Cell Biology, 2020
Although pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear. PD-L1 has been detected in the nucleus, with unknown function.
Junwei Hou, Rongce Zhao, W. Xia, Chiung-Wen Chang, Y. You, Jung-Mao Hsu, L. Nie, Yeh Chen, Yu-Chuan Wang, Chunxiao Liu, Wei‐Jan Wang, Yun Wu, Baozhen Ke, J. Hsu, Ke-Bin Huang, Zu Ye, Yi Yang, Xianghou Xia, Yintao Li, Chia‐Wei Li, B. Shao, J. Tainer, M. Hung   +22 more
semanticscholar   +1 more source

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Nature Communications, 2020
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, the underlying nature and mechanisms driving the involved cell death remain obscure.
Patricia P. Yee, Yiju Wei, Soo-Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, K. Thamburaj, Megan M. Young, D. Aregawi, M. Glantz, B. Zacharia, C. Specht, Hong-Gang Wang, Wei Li   +16 more
semanticscholar   +1 more source

EFFECTS OF LEAD ON HISTOPATHOLOGY OF THE MUSCLES OF Clarias gariepinus JUVENILES

Academy Journal of Science and Engineering, 2022
The acute toxicity test of lead to Clarias gariepinus juveniles in the muscles and intestine of Clarias gariepinus juveniles was investigated using Standard Methods Bioassay APHA(2000).
M.M. Babatunde, A. Y. Idris
doaj  

Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer

Pharmaceuticals, 2023
Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for 50% of total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse ...
Mariana Teixeira Rodrigues, Ana Paula Picaro Michelli, Gustavo Felisola Caso, Paloma Ramos de Oliveira, Dorival Mendes Rodrigues-Junior, Mirian Galliote Morale, Joel Machado Júnior, Karina Ramalho Bortoluci, Rodrigo Esaki Tamura, Tamiris Reissa Cipriano da Silva, Cristiano Raminelli, Eric Chau, Biana Godin, Jamile Calil-Silveira, Ileana G. Sanchez Rubio   +14 more
doaj   +1 more source

Exploring Macrophage-Dependent Wound Regeneration During Mycobacterial Infection in Zebrafish

Frontiers in Immunology, 2022
The molecular and cellular mechanisms associated with tissue degradation or regeneration in an infectious context are poorly defined. Herein, we explored the role of macrophages in orchestrating either tissue regeneration or degradation in zebrafish ...
Candice Bohaud, Matt D. Johansen, Matt D. Johansen, Béla Varga, Rafael Contreras-Lopez, Audrey Barthelaix, Claire Hamela, Dora Sapède, Thierry Cloitre, Csilla Gergely, Christian Jorgensen, Christian Jorgensen, Laurent Kremer, Laurent Kremer, Farida Djouad   +14 more
doaj   +1 more source

Redox State Modulatory Activity and Cytotoxicity of Olea europaea L. (Oleaceae) Leaves Extract Enriched in Polyphenols Using Macroporous Resin

Antioxidants
The food products derived from Olea europaea are a fundamental part of the Mediterranean diet, and their health-promoting effects are well known. In this study, we analyzed the phytochemical characteristics, the redox state modulatory activity, and the ...
Tonia Luca, Giuseppe Antonio Malfa, Laura Siracusa, Alfonsina La Mantia, Simone Bianchi, Edoardo Napoli, Stefano Puleo, Angelo Sergi, Rosaria Acquaviva, Sergio Castorina   +9 more
doaj   +1 more source

Concordancia clínico-patológica en fallecidos en el Hospital Pediátrico de Cienfuegos (2000-2015)

Medisur, 2021
Fundamento: La concordancia y discrepancia de las causas de muerte entre el diagnóstico clínico y el morfológico son, de forma indirecta, indicadores de calidad en la atención hospitalaria, y han tenido un papel fundamental en la educación médica ...
Jorge Luis Capote Padrón, Yusimí García Mena, Ariel Efrén Uriarte Méndez, Alnilam Fernández González, Darian Polls Machado, Dunia María Chávez Amaro   +5 more
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An Observational Study Investigating Potential Risk Factors and Economic Impact for Bovine Ischaemic Teat Necrosis on Dairy Farms in Great Britain

Frontiers in Veterinary Science, 2022
Bovine ischaemic teat necrosis (ITN) is an emerging disease of unknown aetiology that affects the teats of dairy cattle. It causes economic and animal welfare issues with many animals being culled.
Hayley E. Crosby-Durrani, Roger W. Blowey, Al Manning, João Sucena Afonso, Stuart D. Carter, Nicholas J. Evans, Joseph W. Angell   +6 more
doaj   +1 more source

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

Cell Reports, 2018
Summary: Dysfunctions in mitochondrial dynamics and metabolism are common pathological processes associated with Parkinson’s disease (PD). It was recently shown that an inherited form of PD and dementia is caused by mutations in the OPA1 gene, which ...
Angelo Iannielli, Simone Bido, Lucrezia Folladori, Alice Segnali, Cinzia Cancellieri, Alessandra Maresca, Luca Massimino, Alicia Rubio, Giuseppe Morabito, Leonardo Caporali, Francesca Tagliavini, Olimpia Musumeci, Giuliana Gregato, Erwan Bezard, Valerio Carelli, Valeria Tiranti, Vania Broccoli   +16 more
doaj   +1 more source