Results 81 to 90 of about 1,016,672 (340)
Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins
Toxins, 2018 Clostridium perfringens uses its large arsenal of protein toxins to produce histotoxic, neurologic and intestinal infections in humans and animals. The major toxins involved in diseases are alpha (CPA), beta (CPB), epsilon (ETX), iota (ITX), enterotoxin (
Mauricio A. Navarro +2 more
doaj +1 more source
Acid-mediated tumor invasion: How does vasculature affect the growth characteristics? [PDF]
arXiv, 2004 We study the growth of an implanted a-vascular tumor seed in two-dimensions based on a model where the mechanism of invasion is centered on tumor-induced acidification of the micro-environment and consequent death of normal cells. The spatial distribution of the acid density around the tumor is found using mean-field analysis.
arxiv
FEBS Open Bio, EarlyView.This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma +3 more
wiley +1 more source
Skin Necrosis with Oculomotor Nerve Palsy Due to a Hyaluronic Acid Filler Injection
Archives of Plastic Surgery, 2017 Performing rhinoplasty using filler injections, which improve facial wrinkles or soft tissues, is relatively inexpensive. However, intravascular filler injections can cause severe complications, such as skin necrosis and visual loss.
Jae Il Lee, Seok Joo Kang, Hook Sun
doaj +1 more source
Balance between cell survival and death: a minimal quantitative model of tumor necrosis factor alpha cytotoxicity [PDF]
arXiv, 2009 Tumor Necrosis Factor alpha (TNF) initiates a complex series of biochemical events in the cell upon binding to its type R1 receptor (TNF-R1). Recent experimental work has unravelled the molecular regulation of the recruitment of initial signaling complexes that lead either to cell survival or death.
arxiv
Hydrogen sulfide repairs testicular damage induced by heat stress in rats
FEBS Open Bio, EarlyView.Heat stress can cause testicular damage and affect fertility. We investigated the potential protective role of hydrogen sulfide (H2S) against heat stress‐induced testicular injury and observed that H2S donor NaHS can effectively restore testicular damage in rats by inhibiting inflammation and oxidative stress. Our results suggest that H2S might be used
Xinyu Guo +6 more
wiley +1 more source
یافتههای نوین در علوم زیستی, 2015 Cholestasis caused by the excessive accumulation of bile within the liver, due to intrinsic or extrinsic factors. Cholestasis side effects are associated directly or indirectly with the reduction of bile flow and the confinement of materials related to ...
Fatemeh Gharoony +6 more
doaj
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Frontiers in Surgery, 2019 Gastric necrosis with perforation is a rare and potentially life-threatening condition in childhood beyond the neonatal period. We report a case of gastric necrosis and perforation of a portion of the great curvature due to a massive gastric dilatation ...
Zlatan Zvizdic +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source