Results 61 to 70 of about 1,792,338 (310)

Diagnostic Challenges, Prognostic Assessment, and Treatment Strategies in High-Grade Differentiated Thyroid Carcinoma [PDF]

Endocrinology and Metabolism
High-grade differentiated thyroid carcinoma (HGDTC) is a recently codified entity in the 2022 World Health Organization Classification of Endocrine Tumors, defined by a mitotic count of ≥5 mitoses per 2 mm² and/or tumor necrosis in a carcinoma that ...
Chan Kwon Jung, Agnes Stephanie Harahap
doaj   +1 more source

Occurrence of acute oesophageal necrosis (black oesophagus) in a single tertiary centre [PDF]

, 2019
Acute oesophageal necrosis (AON) is a rare condition characterised by the endoscopic finding of diffuse, circumferential, black mucosal pigmentation of the oesophagus, which typically stops at the gastro-oesophageal junction.
Annibale, Bruno, Carabotti, Marilia, Corleto, Vito Domenico, DI GIULIO, Emilio, Esposito, Gianluca, Orlando, Davide, Ruggeri, Maurizio   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Pathological Features of Breast Cancer seen in Northwestern Tanzania: A Nine Years Retrospective Study. [PDF]

, 2011
Breast cancer is more common in Western Countries compared to African populations. However in African population, it appears that the disease tends to be more aggressive and occurring at a relatively young age at the time of presentation. The aim of this
A Dobi, A Fregene, A Gondos, A Stark, C Maureen, CR Barkley, CW Elston, CW Elston, CY Mimi, D Huo, DE Henson, DM Parkin, DM Parkin, EJ Rafael, FA William, G Zavagno, H Amir, H Amir, H Amir, Kahima J Jackson, M Galukande, Mange M Manyama, MK Sheikh, O Ikpatt, O Ikpatt, OF Ikpatt, P Chatzidaki, P Robbins, Peter F Rambau, Philipo L Chalya, RD Leek, RL Bowen, T Hanagiri, T Hasebe   +33 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation

Frontiers in Immunology, 2020
Clearance of cellular debris is required to maintain the homeostasis of multicellular organisms. It is intrinsic to processes such as tissue growth and remodeling, regeneration and resolution of injury and inflammation.
Johannes Westman, Sergio Grinstein, Sergio Grinstein, Sergio Grinstein, Pedro Elias Marques   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bacteremia and conventional diagnosis of Sphingobacterium spiritivorum. A case report

Medisur, 2003
This is a case report of septicaemia due to Sphingobacterium Spiritovirum that caused acute symmetric acronecrosis in a previously healthy man who received medical assistance at the University Hospital ¨Dr.
Elio Jesús Núñez Tamayo, Susana Chamero Melgarejo, Rafael Gómez Marrero, Nancy Ramírez Martínez, Eva María García Mauri, Remberto González Enoa   +5 more
doaj  

Assessment of interactions between defoliation and Phytophthora plurivora stem infections of birch seedlings

The Forestry Chronicle, 2018
Silver birch, (Betula pendula), is an important forest tree species in Poland used for afforestation in rural areas and planted in wet forest types to ameliorate excess water. Physiological stress may increase susceptibility of trees to disease and it is
Tomasz Oszako, Dzmitry Voitka, Miłosz Tkaczyk, Nenad Keča, Lassaâd Belbahri, Justyna A. Nowakowska   +5 more
doaj   +1 more source