Results 41 to 50 of about 51,910 (254)

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Association of intestinal alkaline phosphatase with necrotizing enterocolitis among premature infants [PDF]

, 2019
Importance: Necrotizing enterocolitis (NEC) in preterm infants is an often-fatal gastrointestinal tract emergency. A robust NEC biomarker that is not confounded by sepsis could improve bedside management, lead to lower morbidity and mortality, and permit
Barkemeyer, Brian, Buckley, Rebecca, Davis, Porcha, Fang, Zhide, Gerber, Zeromeh, Gong, Qingqing, Good, Misty, Heath, Maya, Kim, Sunyoung, Linneman, Laura, Penn, Duna   +10 more
core   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Expression and Possible Role of Silent Mating Type Information Regulation 2 Homolog 1 in Post-necrotizing Enterocolitis Stricture in vivo and in vitro

Frontiers in Pediatrics, 2022
PurposeTo investigate the expression and possible role of Sirtuin1 or Silent mating–type information regulation 2 homolog-1 (SIRT1) in post-necrotizing enterocolitis stricture.Materials and MethodsThe expression characteristics of SIRT1 and TGF-β1 in ...
Rui Chen, Chengjie Lv, Yun Zhao, Weizhong Gu, Luyin Zhang, Bo Shi, Jingfa Tou   +6 more
doaj   +1 more source

External validation of calculator for cesarean delivery during induction of labor

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To validate a published risk calculator to predict cesarean delivery (CD) among singletons undergoing induction of labor. Methods Our retrospective cohort study included singletons undergoing induction of labor. A predicted CD score was calculated for each individual based on a previously developed calculator.
Claudia J. Ibarra, Rachel L. Wiley, Han‐Yang Chen, Estefania Guthrie, Ipsita Ghose, Hector Mendez‐Figueroa, Suneet P. Chauhan   +6 more
wiley   +1 more source

Assessment of the state of hemodynamic in the area of superior mesenteric artery in newborns with necrotizing enterocolitis

Неонатологія, хірургія та перинатальна медицина, 2019
The feasibility and effectiveness of superior mesenteric artery Doppler ultrasonography in the diagnosis of necrotizing enterocolitis and other gastrointestinal pathologies in newborns were evaluated in this article. It was found that with in necrotizing
E.A. Artemenko, T.V. Martinyuk, O.M. Gorbatyuk, I.A. Stadnyk, A.A. Pikozh   +4 more
doaj   +1 more source

Dichotomous development of the gut microbiome in preterm infants. [PDF]

, 2018
BackgroundPreterm infants are at risk of developing intestinal dysbiosis with an increased proportion of Gammaproteobacteria. In this study, we sought the clinical determinants of the relative abundance of feces-associated Gammaproteobacteria in very low
Gilbert, Jack A, Groer, Maureen W, Ho, Thao TB, Kane, Bradley, Maheshwari, Akhil, Torres, Benjamin A, Yee, Alyson L   +6 more
core   +1 more source

Long‐term child outcomes after prenatal aspirin exposure: A 4‐year follow‐up of a randomized controlled trial (the APRIL study)

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To identify the long‐term child outcomes after prenatal aspirin exposure. Methods This study is a follow‐up of a randomized controlled trial (RCT) evaluating low‐dose aspirin in the prevention of recurrent spontaneous preterm labor (the APRIL study) comparing aspirin 80 mg daily (n = 194) to placebo (n = 193) in singletons.
Emilie V. J. van Limburg Stirum, Janneke van ’t Hooft, Anadeijda J. E. M. C. Landman, Martijn J. J. Finken, Anita C. J. Ravelli, Aleid G. Leemhuis, Eva Pajkrt, Martijn A. Oudijk, Marjon A. de Boer   +8 more
wiley   +1 more source

Burden and its associated factors of neonatal necrotizing enter colitis among neonates admitted in neonatal intensive care unit in Ethiopia. A systematic review and meta-analysis

International Journal of Africa Nursing Sciences
Neonatal Necrotizing enterocolitis is the most critical and recurrent gastrointestinal disorder in neonatal intensive care units. Although the overall mortality extends to 50 % related to necrotizing enterocolitis, it can approach 100 % with perforation,
Demewoz Kefale, Worku Necho Asferie, Tigabu Munye Aytenew, Gedefaw Abeje Masresha, Mahilet Wondim, Misganaw Abie Tassew, Kidist Hunegn Setargew, Yeshiambaw Eshetie, Solomon Demis Kebede   +8 more
doaj   +1 more source

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure [PDF]

, 2019
Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects.
Ashley, Patricia L., Bain, James R., Cotten, C. Michael, Goldberg, Ronald N., Muehlbauer, Michael J., Newgard, Christopher B., O’Connell, Thomas M., Rawls, John F., Seed, Patrick C., Stevens, Robert D., Younge, Noelle E.   +10 more
core   +1 more source