Results 41 to 50 of about 119,494 (333)

Case Report: Clostridium neonatale Bacteremia in a Preterm Neonate With Necrotizing Enterocolitis

Frontiers in Pediatrics, 2021
Necrotizing enterocolitis is a life-threatening acquired gastrointestinal disorder among preterm neonates and is associated with a high mortality rate and long-term neurodevelopmental morbidity.
Nadim Cassir, Nadim Cassir, Isabelle Grandvuillemin, Manon Boxberger, Manon Boxberger, Priscilla Jardot, Priscilla Jardot, Farid Boubred, Farid Boubred, Bernard La Scola, Bernard La Scola   +10 more
doaj   +1 more source

Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia [PDF]

, 2019
BACKGROUND: Necrotizing enterocolitis (NEC) in premature infants is often a devastating surgical condition with poor outcomes. GYY4137 is a long-acting donor of hydrogen sulfide, a gasotransmitter that is protective against intestinal injury in ...
Drucker, Natalie A., Jensen, Amanda R., Markel, Troy A., Te Winkel, Pieter Jan   +3 more
core   +1 more source

Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study [PDF]

, 2016
BACKGROUND The inflammatory cytokine cascade is implicated in the pathogenesis of necrotising enterocolitis (NEC). Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease ...
Baier, R. J., Brocklehurst, P., Craig, S., Helps, N., Henderson, G., McGuire, W.   +5 more
core   +1 more source

The human milk oligosaccharides 2’-Fucosyllactose and 6’-Sialyllactose protect against the development of necrotizing enterocolitis by inhibiting Toll-Like Receptor 4 signaling.

Pediatric Research, 2020
Background Necrotizing enterocolitis (NEC) develops through exaggerated toll-like receptor 4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible oligosaccharides and prevents NEC through unclear mechanisms.
C. Sodhi, P. Wipf, Yukihiro Yamaguchi, W. Fulton, M. Kovler, D. Niño, Qinjie Zhou, E. Banfield, A. Werts, Mitchell R. Ladd, R. Buck, Karen C. Goehring, T. Prindle, Sanxia Wang, H. Jia, Peng Lu, D. Hackam   +16 more
semanticscholar   +1 more source

Necrotizing enterocolitis: controversies and challenges [version 1; referees: 3 approved]

F1000Research, 2015
Necrotizing enterocolitis is a devastating intestinal disease that affects ~5% of preterm neonates. Despite advancements in neonatal care, mortality remains high (30–50%) and controversy still persists with regards to the most appropriate management of ...
Augusto Zani, Agostino Pierro
doaj   +1 more source

Immediate Post-operative Enterocyte Injury, as Determined by Increased Circulating Intestinal Fatty Acid Binding Protein, Is Associated With Subsequent Development of Necrotizing Enterocolitis After Infant Cardiothoracic Surgery

Frontiers in Pediatrics, 2020
Objectives: 1 Measure serial serum intestinal fatty acid binding protein levels in infants undergoing cardiac surgery with cardiopulmonary bypass to evaluate for evidence of early post-operative enterocyte injury.
John D. Watson, Tracy T. Urban, Suhong S. Tong, Jeanne Zenge, Ludmilla Khailova, Paul E. Wischmeyer, Jesse A. Davidson   +6 more
doaj   +1 more source

Enteric dysbiosis and fecal calprotectin expression in premature infants. [PDF]

, 2019
BackgroundPremature infants often develop enteric dysbiosis with a preponderance of Gammaproteobacteria, which has been related to adverse clinical outcomes.
A Ghidini, AG Roseth, Akhil Maheshwari, Alyson L. Yee, BC MacQueen, Benjamin A. Torres, Bradley Kane, BS Fullerton, C Rouge, C Urbaniak, CJ Stewart, D Boccia, D Canioni, DC Straus, EA Albanna, F Sommer, FJ Verdam, HH Stone, HM Moore, HR Hill, J Penders, Jack A. Gilbert, JM Rhoads, JP Gisbert, LM Kindinger, M Pammi, M Zhang, Maureen W. Groer, MC Lu, MS Goyal, N Gregersen, PD Smith, PJ Turnbaugh, R Cortese, RM Torrazza, RM Torrazza, SH Patel, Thao T. B. Ho, TTB Ho, VK Gupta, Y Wang, Y Zhou   +41 more
core   +2 more sources

CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants

Journal of Experimental Medicine, 2021
Using single-cell analysis of whole blood and intestinal tissue, Olaloye et al. identify a population of inflammatory monocytes that are potentially pathogenic in necrotizing enterocolitis.
Oluwabunmi O Olaloye, P. Liu, Jessica M Toothaker, B. McCourt, C. McCourt, Jenny Xiao, E. Prochaska, Spenser Shaffer, L. Werner, Jordan Gringauz, M. Good, J. Goldsmith, Xiaojing An, Fujing Wang, S. Snapper, D. Shouval, Kong Chen, G. Tseng, Liza Konnikova   +18 more
semanticscholar   +1 more source

Association of Chorioamnionitis with Aberrant Neonatal Gut Colonization and Adverse Clinical Outcomes. [PDF]

, 2016
ObjectiveChorioamnionitis (inflammation of the placenta and fetal membranes) and abnormal gastrointestinal colonization have been associated with an increased risk of sepsis and death in preterm infants, but whether chorioamnionitis causes abnormal ...
Ambalavanan, Namasivayam, Kallapur, Suhas G, Morrow, Ardythe L, Puri, Kriti, Schibler, Kurt R, Taft, Diana H   +5 more
core   +1 more source

ULTRASOUND DIAGNOSIS OF NECROTIZING ENTEROCOLITIS

Медицинский совет, 2018
The necrotizing enterocolitis remains the basic disease leading to a mortality of mainly prematurely born children with low and extremely low body weight.
M. I. Pykov, V. V. Balashov, E. A. Filippova, V. Y. Bosin, Ch. M. Khizroeva   +4 more
doaj   +1 more source