Results 51 to 60 of about 46,257 (278)

Necrotizing Enterocolitis: The Future [PDF]

Neonatology, 2020
Progress in our understanding of the pathophysiology, prevention and treatment of necrotizing enterocolitis (NEC) has been hampered for many reasons. Included among these is the fact that what we are calling “NEC” is likely to represent different disease processes, which need to be delineated before evaluating individual pathogenic mechanisms and ...
openaire   +2 more sources

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Expression and Possible Role of Silent Mating Type Information Regulation 2 Homolog 1 in Post-necrotizing Enterocolitis Stricture in vivo and in vitro

Frontiers in Pediatrics, 2022
PurposeTo investigate the expression and possible role of Sirtuin1 or Silent mating–type information regulation 2 homolog-1 (SIRT1) in post-necrotizing enterocolitis stricture.Materials and MethodsThe expression characteristics of SIRT1 and TGF-β1 in ...
Rui Chen, Chengjie Lv, Yun Zhao, Weizhong Gu, Luyin Zhang, Bo Shi, Jingfa Tou   +6 more
doaj   +1 more source

Bifidobacterium longum subsp. infantis in experimental necrotizing enterocolitis: alterations in inflammation, innate immune response, and the microbiota. [PDF]

, 2014
BackgroundProbiotics decrease the risk of necrotizing enterocolitis (NEC). We sought to determine the impact of Bifidobacterium longum subsp. infantis (B. infantis) in the established rat model of NEC.MethodsRat pups delivered 1 d prior to term gestation
Arriola, Jennifer, Bevins, Charles L, Dvorak, Bohuslav, Gerber, Colin W, Kalanetra, Karen M, Kananurak, Anchasa, Kaveti, Ashwini, Mills, David A, Underwood, Mark A   +8 more
core   +1 more source

Probiotics and necrotizing enterocolitis [PDF]

Seminars in Pediatric Surgery, 2018
In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). We review the role of the microbiome in NEC and pre-clinical data on mechanisms of probiotic action. Next, we summarize existing randomized controlled trials and observational studies of probiotics to prevent NEC.
Ravi Mangal, Patel, Mark A, Underwood
openaire   +2 more sources

Ocrelizumab‐induced colitis: VigiBase disproportionality analysis, case reports and literature review

British Journal of Clinical Pharmacology, EarlyView.
Aims Ocrelizumab is a humanized anti‐CD20 monoclonal antibody used in multiple sclerosis. Since its commercialization, several cases of ocrelizumab‐induced colitis have been reported in the scientific literature. Methods To explore the potential association of ocrelizumab with colitis as an adverse drug reaction (ADR), we conducted a descriptive and ...
Audrey Fresse, Christophe Hommel, Nadine Petitpain, Philippe Kerschen   +3 more
wiley   +1 more source

Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial [PDF]

, 2019
Background Infections acquired in hospital are an important cause of morbidity and mortality in very preterm infants. Several small trials have suggested that supplementing the enteral diet of very preterm infants with lactoferrin, an antimicrobial ...
Ainsworth, S, Bartle, D, Batra, D, Baum, A, Berrington, J, Bowler, U, Boyle, E, Bradburn, M, Clarke, P, Cooke, R, Craig, S, Dorling, J, ELFINTI Grp, Ellis, S, Embleton, N, Ewer, A, Garg, S, Geethanath, R, Gibson, D, Gowda, G, Griffiths, J, Gupta, R, Halliday, H, Heath, P, Hellier, J, Holder, G, Hutchison, F, Janakiraman, S, Jenkins, P, Johnson, K, Johnson, M, Juszczak, E, Kennea, N, King, A, Kumar, Y, Ledwidge, M, Linsell, L, Mactier, H, Manjunatha, CM, Mannix, P, Matthes, J, McGuire, W, Millar, M, Murray, D, Oddie, S, Ohadike, P, Partlett, C, Patel, M, Peters, C, Piling, E, Quine, D, Reynolds, P, Roehr, C, Scorrer, T, Story, I, Subhedar, N, Vailcutz, R, Vargova, M, Vasu, V, Yates, H   +59 more
core   +2 more sources

Burden and its associated factors of neonatal necrotizing enter colitis among neonates admitted in neonatal intensive care unit in Ethiopia. A systematic review and meta-analysis

International Journal of Africa Nursing Sciences
Neonatal Necrotizing enterocolitis is the most critical and recurrent gastrointestinal disorder in neonatal intensive care units. Although the overall mortality extends to 50 % related to necrotizing enterocolitis, it can approach 100 % with perforation,
Demewoz Kefale, Worku Necho Asferie, Tigabu Munye Aytenew, Gedefaw Abeje Masresha, Mahilet Wondim, Misganaw Abie Tassew, Kidist Hunegn Setargew, Yeshiambaw Eshetie, Solomon Demis Kebede   +8 more
doaj   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Comparison of necrotizing enterocolitis (NEC)-related apoptosis factors between preterm and full-term rats

Scientific Reports
The aim of this study was to determine whether there is a difference in the degree of apoptosis and the pathways leading to necrotizing enterocolitis (NEC) between preterm and full-term rat pups.
Hye-rim Lee, Dayoung Ko, Kyeung Yeup Lee, So young Kim, Joong Kee Youn, Hee Beom Yang, Hyun-Young Kim   +6 more
doaj   +1 more source